Quanjun Wang
Academy of Military Medical Sciences
11 Papers
54 Citations
Quanjun Wang is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Medicine & Nephrotoxicity. The author has an hindex of 6, co-authored 8 publications.
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Papers
Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity.
Ronghui Lei,Chunqi Wu,Baohua Yang,Huazhai Ma,Chang Shi,Quanjun Wang,Qingxiu Wang,Ye Yuan,Mingyang Liao +8 more
TL;DR: The data generated from the current study completely supports the fact that an integrated metabolomic approach is promising for the development of a rapid in vivo screening method for nanotoxicity.
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Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine, blood plasma, and liver extracts
Quanjun Wang,Ying Jiang,Chunqi Wu,Jianyu Zhao,Shouzhong Yu,Benli Yuan,Xianzhong Yan,Mingyang Liao +7 more
TL;DR: The results indicate that in rats Z24 inhibits mitochondrial function through altering the energy and lipid metabolism, which results in the accumulation of free fatty acids and lactate because of the lack of aerobic respiration.
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Proteomics unite traditional toxicological assessment methods to evaluate the toxicity of iron oxide nanoparticles
Junyuan Han,Yong-Chao Tian,Minghan Wang,Yajuan Li,Jiye Yin,Wen-sheng Qu,Chang-Hui Yan,Rigao Ding,Yongbiao Guan,Quanjun Wang +9 more
TL;DR: The spleen was the primary organ for IONPs elimination from the systemic circulation and that the macrophage lysosomes were the main organelles of IonPs accumulation after intravenous administration, and 197 upregulated and 75 downregulated proteins in the spleen were identified by proteomics.
Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats.
Ying Wang,Baohua Yang,Chunqi Wu,Zhibing Zheng,Ye Yuan,ZhongHui Hu,Ma Huazhi,Song Li,Mingyang Liao,Quanjun Wang +9 more
TL;DR: In conclusion, inhibition of carbohydrate aerobic oxidation, fatty acid β‐oxidation, and oxidative phosphorylation is a potential mechanism of Z24‐induced hepatotoxicity, resulting in mitochondrial dysfunction and apoptosis‐mediated cell death.
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A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms
Xing Fan,Jiabo Wang,Lihua Xie,Dong Yansheng,Han Gang,Dan Hu,Yue Liu,Benli Yuan,Wang Hemei,Chunqi Wu,Xiaohe Xiao,Rigao Ding,Quanjun Wang +12 more
TL;DR: Activated by LPS, this rat model of DILI for PMT was established successfully and its potential association with TLR4 was established and serum microRNA-122 might be used as a candidate biomarker forPMT-DILI.
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