Quan Wan
6 Papers
Quan Wan is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 6 publications.
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Papers
Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma
Lingli Gong,Ying-Chun Yin,Cheng Chen,Quan Wan,Die Xia,Meilin Wang,Zhening Pu,Bo Zhang,Jian-Gang Zou +8 more
TL;DR: This article developed an acquired TMZ resistant xenograft model using serial implantation of MGMT-hypermethylated U87 cells, allowing the extraction of stable, TMZ resistant (TMZ-R) tumors and primary cells.
SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization
Jingjing Wang,Zixuan Huang,Linong Ji,Cheng Chen,Quan Wan,Yu Xin,Zhening Pu,Jiantong Jiao,Ying-Chun Yin,Yaling Hu,Lingli Gong,Rui Zhang,Xusheng Yang,Xiangming Fang,Mei Wang,Junfei Shao,Jian Zou +16 more
TL;DR: Targeting of the SHF/STAT3 interaction is identified as a promising strategy for developing an optimal STAT3 inhibitor and early evidence of the potential clinical efficacy of STAT3 inhibitors such as C16 in GBM is provided.
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TRAF4 maintains deubiquitination of Caveolin-1 to drive glioblastoma stemness and Temozolomide resistance.
Yongxu Li,Tiepeng Wang,Quan Wan,Qing Wang,Zhenzhong Chen,Yuan Gao,Yuchen Ye,Jiusheng Lin,Bihuan Zhao,Huaile Wang,Jinming Yang,Kai Zhao,Na Lu +12 more
TL;DR: It is reported that TRAF 4 is preferentially overexpressed in GSCs and is required for stem-like properties as well as TMZ sensitivity in GBM cells, and pharmacological inhibition of TRAF4 with Risperidone potently inhibited self-renewal, abrogated tumorigenicity, and reversed TMZ resistance in G BM.
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Irisin promotes the proliferation and tenogenic differentiation of rat tendon-derived stem/progenitor cells via activating YAP/TAZ
TL;DR: In this paper , irisin treatment increased the proliferative and colony-forming abilities, and promoted the tenogenic differentiation of tendon-derived stem/progenitor cells (TSPCs) by upregulating the expression of YAP/TAZ.
Effect of gut microbiome regulated Taohong Siwu Decoction metabolism on glioma cell phenotype
TL;DR: In this paper , Taohong Siwu Decoction (TSD) was fed to germ-free mice and conventional mice, respectively, and the serum from both groups of mice was removed and co-cultured with glioma cells in vitro.