Qiujie Wang
Laboratory of Molecular Biology
13 Papers
6 Citations
Qiujie Wang is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications.
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Papers
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
TL;DR: In this article, the role and underlying molecular mechanisms of GSTZ1 in sorafenib-induced ferroptosis in hepatocellular carcinoma (HCC) were investigated.
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
TL;DR: GSTZ1 deficiency was resistant to sorafenib-induced ferroptosis and is, therefore, a potential therapeutic approach for treating HCC by synergizing sorafinib and RSL3 to induce ferroPTosis.
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
Jingjing Li,Jingjing Li,Qiujie Wang,Yi Yang,Chong Lei,Fan Yang,Li Liang,Chang Chen,Jie Xia,Kai Wang,Ni Tang +10 more
TL;DR: GSTZ1 serves as a tumor suppressor in HCC and the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of GstZ1-knockout HepG2 cells and HCC progression in Gstz1−/− mice.
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Fan Yang,Fan Yang,Jingjing Li,Haijun Deng,Yihao Wang,Chong Lei,Qiujie Wang,Jin Xiang,Li Liang,Jie Xia,Xuanming Pan,Xiaosong Li,Quanxin Long,Lei Chang,Ping Xu,Ailong Huang,Kai Wang,Ni Tang +17 more
TL;DR: It is revealed that GSTZ1‐1, the enzyme in phenylalanine/tyrosine catabolism, is downregulated in HCC, and its expression was negatively correlated with IGF1R, establishing succinylacetone as an oncometabolite, and GSTZ 1‐1 as an important tumor suppressor by inhibiting NRF2/IGF1R axis in H CC.
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Effects of Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio
TL;DR: In this paper , the authors investigated the effect of koukmine (KM) on the growth of C. carpio and found that KM had a growth-promoting effect that was related to cell proliferation driven by the TGF-β1/Smad, MAPK, and Jak/Stat signaling pathways.