Qiuchan Xiong
Sichuan University
13 Papers
3 Citations
Qiuchan Xiong is an academic researcher from Sichuan University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 5 publications.
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Papers
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
Maosheng Cheng,Lu Sheng,Qian Gao,Qiuchan Xiong,Haojie Zhang,Mingqing Wu,Yu Liang,Fengyu Zhu,Yingyin Zhang,Xiuhong Zhang,Quan Yuan,Yang Li +11 more
TL;DR: An AFF4/NF-κB/MYC signaling network operated by METTL3-mediated m6A modification is uncovered and insight into the mechanisms of BCa progression is provided.
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Mettl3-mediated m 6 A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
Yunshu Wu,Liang Xie,Mengyuan Wang,Qiuchan Xiong,Yuchen Guo,Yu Liang,Jing Li,Rui Sheng,Peng Deng,Yuan Wang,Rixin Zheng,Yi-Zhou Jiang,Ling Ye,Qianming Chen,Xuedong Zhou,Shuibin Lin,Quan Yuan +16 more
TL;DR: It is shown that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.
METTL3-Mediated m6A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway.
Yu Liang,Yu Liang,Hui Han,Qiuchan Xiong,Chunlong Yang,Lu Wang,Jieyi Ma,Shuibin Lin,Yi-Zhou Jiang +8 more
TL;DR: Zhang et al. as discussed by the authors showed that METTL3-m6A-YTHDF1 axis regulates the mRNA translation of Notch signaling pathway, which plays important functions in posttranscriptional gene expression regulation and various biological processes.
AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.
Chenchen Zhou,Qiuchan Xiong,Xinxing Zhu,Wen Du,Peng Deng,Peng Deng,Xiaobing Li,Yi-Zhou Jiang,Shujuan Zou,Cun-Yu Wang,Quan Yuan +10 more
TL;DR: It is shown that small interfering RNA-mediated depletion of AFF1 in human MSCs leads to increased alkaline phosphatase (ALP) activity, enhanced mineralization and upregulated expression of osteogenic-related genes, and depletion of BMP2-induced AFF4 significantly inhibits the osteogenic potential of M SCs.
CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling
Caojie Liu,Qiuchan Xiong,Qiwen Li,Weiming Li,Shuang Jiang,Danting Zhang,Yan Wang,Xiaobo Duan,Ping Gong,Ning Kang +9 more
TL;DR: In this paper , a conditional knockout of Chd7 in bone marrow mesenchymal stem cells (MSCs) and preosteoblasts leads to a pathological phenotype manifested as low bone mass and severely high marrow adiposity.
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