17 Papers
35 Citations
Qiong Wei is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Qiong Wei include University of Bologna & Fox Chase Cancer Center.
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Papers
Testing computational prediction of missense mutation phenotypes: Functional characterization of 204 mutations of human cystathionine beta synthase
TL;DR: A set of random mutations of the enzymatic domains of human cystathionine beta synthase was derived to infer the phenotypes of 204 single‐site mutants, 79 of them deleterious and 125 neutral, and it was found that the difference in position‐specific scoring matrix values is more predictive than the wild‐type PSSM score alone.
CD45-deficient severe combined immunodeficiency caused by uniparental disomy
Joseph L. Roberts,Rebecca H. Buckley,Biao Luo,Jianming Pei,Alla Lapidus,Suraj Peri,Qiong Wei,Jinwook Shin,Roberta E. Parrott,Roland L. Dunbrack,Joseph R. Testa,Xiao-Ping Zhong,David L. Wiest +12 more
TL;DR: These findings are unique in representing a reported case of SCID caused by UPD and suggest UPD should be considered in SCID and other recessive disorders, especially when the patient appears homozygous for an abnormal gene found in only one parent.
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Cyanine 5.5 Conjugated Nanobubbles as a Tumor Selective Contrast Agent for Dual Ultrasound-Fluorescence Imaging in a Mouse Model
Liyi Mai,Anna Yao,Jing Li,Qiong Wei,Ming Yuchi,Xiaoling He,Mingyue Ding,Qibing Zhou,Qibing Zhou +8 more
TL;DR: C cyanine 5.5 conjugated nanobubbles of a biocompatible chitosan–vitamin C lipid system as a dual ultrasound-fluorescence contrast agent that achieved tumor-selective imaging in a mouse tumor model is reported on.
Prediction of phenotypes of missense mutations in human proteins from biological assemblies.
TL;DR: It is found that mutations in the core of proteins or in the interfaces in biological assemblies are significantly more likely to be disease‐associated than those on the surface of the biological assemblies.
23
Design, Synthesis, and In Vitro and In Vivo Biological Studies of a 3′-Deoxythymidine Conjugate that Potentially Kills Cancer Cells Selectively
TL;DR: dT-QX is the first molecule of its kind with highly amendable constituents that exhibits this selective cytotoxicity in cancer cells, and covalent linkage with 3′-deoxythymidine uniquely directed cytotoxic phenylquinoxaline moiety more toward cancer cells than normal cells.