Obesity during perimenopausal transition can be attributed to various factors. Identifying these factors is crucial in preventing obesity and developing effective strategies to manage weight during this phase. This review aimed to systematically understand predictors of obesity during menopausal transition. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and searched databases like PubMed, Wiley Online Library, and Cochrane Reviews. Cohort and cross-sectional studies in English language assessing obesity among menopausal women were included. The methodological quality was assessed using Joanna Briggs Checklist for critical appraisal. Risk of Bias (RoB) was generated using Review Manager 5.4.1 (RevMan). Identified predictors were assessed for overall quality of evidence using adopted Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. This review encompassed 42 studies, (21 cross-sectional and 21 cohort) with sample ranging from 164 to 107,243 across studies. Higher parity( ≥ 3 children) emerged as a strong predictor of obesity across seven studies, with good-quality evidence. Lower physical activity was another predictor, supported by eight studies with good-quality evidence. Sociodemographic factors like lower education(<8 years or < than college degree), socioeconomic background, menopausal transition, and older age at menarche showed associations with weight gain, with moderate-quality evidence. Lifestyle factors (high-fat consumption, sedentariness, active smoking status, and psychological difficulties) also showed moderate-quality evidence. This review underscores the multifaceted factors associated with obesity during the perimenopausal transition. Identifying these factors will be helpful in prevention and management of obesity among these women. 

A comprehensive evaluation of predictors of obesity in women during the perimenopausal period: A systematic review and narrative synthesis

Previous studies have found that TLR4 rs1928295 polymorphism is associated with Body Mass Index in European and American Indian adults. This study evaluates the relationship between this locus polymorphism, obesity-related parameters and dietary patterns in Chinese Han Children. A total of 798 children aged 7-12 years were included in this cross-sectional study. An improved Multiple Ligase Detection Reaction was used for genotyping. Dietary patterns were identified by principal component factor analysis. The overweight/obesity rate of the TT genotype was greater than those of the CC/CT genotype (p = 0.032 and 0.048 in boys and girls, respectively). Boys of the TT genotype could interact with protein and cholesterol intake to increase low density lipoprotein (LDL) levels (p = 0.02, 0.015, respectively), while girls of the TT genotype could interact with total energy intake to increase triglyceride (TG) (p = 0.018) levels. Boys predisposed to a healthy balance dietary pattern (HBDP) and girls predisposed to an egg/fruit/fish dietary pattern (EFDP) were significantly associated with lower rates of central obesity (p = 0.045, 0.028). Boys carrying the TT genotype and predisposed to animal food dietary pattern (AFDP) had a higher level of low-density lipoprotein (p = 0.017) and systolic pressure (p = 0.044). Our results indicated that the TT genotype of TLR4 rs1928295 is a potential risk factor for obesity in Chinese Han children and is associated with dietary patterns. 

TT Genotype of TLR4 rs1928295 Is a Risk Factor of Overweight/Obesity in Han Chinese Children Aged 7–12 Years and Can Interact with Dietary Patterns to Affect the Incidence of Central Obesity and Lipid Profile, Systolic Blood Pressure Levels

Background The level of mobility and general health has decreased among students in virtual classes during COVID-19 pandemic. The present cross-sectional study aims to investigate the mental and physical conditions related to inactivity among the students of Farhangian University during the virtual classes. Methods This is a cross-sectional study. 475 students (214 females and 261 males) were selected as the statistical sample of the study based on Morgan’s Table from Farhangian University, Iran. The statistical population includes students studying at Farhangian University of Mazandaran province that using Convenience Sampling the sample size based on Morgan’s Table, 475 students consisting of 214 females and 261 males were randomly selected as the statistical sample of the study. The research instruments of this study include International Physical Activity Questionnaire, Saehan Caliper (SH5020), Coopersmith Self-Esteem Scale, Beck Depression Questionnaire, and Nordic Skeletal and Muscular Disorders Questionnaire. For data analysis, independent sample t-test was employed to compare two groups. All analyses were conducted using spss24 software. Results With respect to students’ skeletal-muscular disorders, findings proved that both genders suffered physical conditions during virtual classes. The research findings showed that the average weekly activity level among women is 634 Met/min with a standard deviation of ±281, and the average weekly activity level among men is 472 Met/min with a standard deviation of ±231. Fat percentage by gender, men’s average fat percentage is 47.21% (S. D ± 4.74) and women’s average fat percentage is 31.55% (S. D ± 4.37). Also, the self-esteem scores of male and female students were obtained 29.72 and 29.43, respectively, and the difference between the two was considered significant (p < 0.05). On the other hand, 67% (No. 25) of female students and 32% (No. 12) of male students suffered from high depression. Also, based on students’ skeletal-muscular disorders, findings of our study showed that both genders suffered physical conditions during virtual classes. Conclusion This study suggests increasing the level of physical activity to reduce body fat mass, increase mental health and reduce skeletal disorders, which can be properly accomplished through university planning and prioritizing the health of male and female students.

/pdf/mental-and-physical-conditions-associated-with-physical-25npj6qs.pdf

Mental and physical conditions associated with physical inactivity among Farhangian University students during virtual classes: A cross-sectional study

Objective: The level of mobility and general health has decreased among students in virtual classes during the COVID-19 pandemic. The present study aims to investigate the mental and physical complications caused by inactivity among the students of Farhangian University during virtual classes. Methods: This was survey research with a cross-sectional design. The statistical population included all male and female students studying at Farhangian University of Mazandaran Province, Iran. According to the determination of the sample size based on the Morgan table, 475 students, consisting of 214 females and 261 males, were randomly selected as the statistical sample of the study. The research instruments include the international physical activity questionnaire, Saehan Caliper (SH5020), the Coopersmith self-esteem scale (1967), the Beck depression questionnaire, and the Nordic skeletal and muscular disorders questionnaire. To analyze the data, we used the independent sample t test to compare the two groups. All analyses were conducted using the SPSS software, version 24. Results: The research findings showed that the average weekly activity level among women was 634±281 MET/min, and the average weekly activity level among men was 472 ±231 MET/min. In terms of fat percentage by gender, men’s average fat percentage was 21.47%±4.74%, and women’s average fat percentage was 31.55%±4.37%. Meanwhile, the self-esteem scores of male and female students were obtained at 29.72 and 29.43, respectively. The difference between the two was considered significant as P<0.05. In addition to these findings, the correlation between self-esteem and activity level was +0.41. On the other hand, 25(67%) female students and 12(32%) male students suffered from high depression. Conclusion: Concerning students’ skeletal-muscular disorders, findings proved that both genders suffered from physical complications during virtual classes. This study suggests increasing the level of physical activity to reduce body fat mass, increase mental health, and reduce skeletal disorders, which can be properly accomplished through university planning and prioritizing the health of male and female students.

/pdf/investigating-psychic-and-body-complications-caused-by-hqqr7qsh.pdf

Investigating Psychic and Body Complications Caused by Inactivity Among Students of University During the COVID-19 Pandemic

Abstract Background: Central obesity is strongly associated with obesity-related and metabolic diseases, which is a common health problem in sedentary adults, particularly in women, but the mechanisms remain unclear. This study aimed to investigate the prevalence and factors associated with central obesity in white-collar workers Chinese population, and explore potential sex differences. Methods: A cross-sectional study was conducted between 2017 and 2019 at two large general hospitals in northern and southern China. Totally 6,081 white-collar workers underwent a physical examination and completed an online health self-report questionnaire, which included demographic variables, lifestyle factors and blood lipid test. Multilevel logistic regression analysis was performed to assess the prevalence and factors of central obesity. Results: A total of 4,973 male and 1,108 female white-collar workers were included in this study, and the incidence of central obesity was 67.5% and 30.1%, respectively. In male white-collar workers, increasing age, chronic disease, higher levels of total cholesterol, salt intake and BEE, social engagement, eating spicy food and animal offal were risk factors for central obesity, while a higher HDL-C level, eating fish, and high vegetable intake were protective factors. In female white-collar workers, increasing age, higher total cholesterol level, higher BEE, and overeating were risk factors for central obesity, while a higher HDL-C level, and drinking milk were protective factors. Conclusions: Central obesity was a significant public health concern and the prevalence was high in Chinese adults. Healthy lifestyles and dietary measures to control the rates of central obesity should be undertaken to circumvent the growing disease burden in Chinese people.. 

/pdf/the-prevalence-and-modifiable-lifestyle-factors-of-central-rb4m0bgf.pdf

The prevalence and modifiable lifestyle factors of central obesity among white-collar workers of different genders: A cross-sectional study

(1) Background: The prevalence of central obesity is growing rapidly among women, and the prevalence differs by menopausal status. Longer sedentary time and less fruit/vegetable (F/V) intake increased the risk of central obesity. Among women of different menopausal statuses, controversy surrounds the association between sedentary time or F/V intake and central obesity. This study aimed to explore whether the independent and joint associations between sedentary time or F/V intake and menopausal status are correlated with central obesity, respectively. (2) Methods: This cross-sectional study was conducted in Hunan, China. Self-reported questionnaires were used to gather information on demographic characteristics, menopausal status, sedentary time, and F/V intake. Waist circumference was measured at the study site. Binary logistic regression and multiple interaction models were used to explore the independent and joint associations of menopausal status and the above two lifestyle variables with central obesity. (3) Results: A total of 387 women with a mean age of 47.7 ± 6.6 years old participated in the study. The prevalence of central obesity was 52.8%. Peri- and post-menopause statuses and not taking five servings of F/V per day were risk factors of central obesity (p < 0.05), whereas no significant association was found between sedentary time and central obesity (p > 0.05). Among peri-menopausal (mutual odds ratio (OR): 2.466, 95% confidence interval [CI]: 0.984–6.182; p < 0.05) and post-menopausal women (mutual OR: 2.274, 95% CI: 1.046–4.943; p < 0.05), more than 4 h of sedentary time per day was associated with a high risk of central obesity. Among pre-menopausal women, the consumption of five servings of F/V per day was associated with a low risk of central obesity (mutual OR: 0.444, 95%CI: 0.236–0.837, p < 0.05). (4) Conclusions: More than half of women in the central south of China presented with central obesity, spent >4 h of sedentary time per day, or did not engage in recommended F/V intake. Healthier lifestyle intervention is warranted to prevent central obesity development, including reducing the sedentary time to <4 h per day for peri- and post-menopausal women, while increasing taking five servings of F/V per day for pre-menopausal women.

/pdf/does-the-association-of-sedentary-time-or-fruit-vegetable-15mu4kxk.pdf

Does the Association of Sedentary Time or Fruit/Vegetable Intake with Central Obesity Depend on Menopausal Status among Women?

Background Depressive symptoms are prevalent in persons with type 2 diabetes mellitus and related with poor disease outcomes. Both general self-efficacy and coping style are associated with depressive symptoms. A model about proactive coping indicates that coping style plays a mediation role between general self-efficacy and depressive symptoms. But, empirical evidence is missing about this potential mediation relationship which may be a barrier of taking precise strategies for relieving depressive symptoms. Objective This study aims to investigate the prevalence of elevated depressive symptoms in persons with type 2 diabetes mellitus and explore whether coping style preference mediates the association between general self-efficacy and depressive symptoms. Methods This was a secondary data analysis of a cross-sectional survey (June–July 2017) among 721 persons with type 2 diabetes mellitus (45.4% male and 54.6% female) aged from 22 to 96 years old. Data on general self-efficacy, coping style preference and depressive symptoms were collected using validated questionnaires in hospital setting. The mediation model was tested using the bootstrapping (K=5000) in the MPlus program version 7.4. The results were reported following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Results The prevalence of elevated depressive symptoms was 58% (n = 418) among persons with type 2 diabetes mellitus at hospital setting. A higher level of general self-efficacy was related to less depressive symptoms via positive coping preference (p < 0.01). Discussion About two-thirds of persons with type 2 diabetes mellitus experienced elevated depressive symptoms during hospitalization. The intervention elements, including strengthening general self-efficacy and promoting positive coping, are promising to decrease their depressive symptoms.

https://www.dovepress.com/getfile.php?fileID=83729

The Association Between General Self-Efficacy and Depressive Symptoms in People with Type 2 Diabetes Mellitus: The Mediating Role of Coping Styles Preference

The effect of sleep quality on glucose variability among adolescents with type 1 diabetes in China: A multi-central temporal longitudinal association analysis

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Does the Association of Sedentary Time or Fruit/Vegetable Intake with Central Obesity Depend on Menopausal Status among Women?

The Association Between General Self-Efficacy and Depressive Symptoms in People with Type 2 Diabetes Mellitus: The Mediating Role of Coping Styles Preference

The effect of sleep quality on glucose variability among adolescents with type 1 diabetes in China: A multi-central temporal longitudinal association analysis