Qing Yang
Wuhan University
21 Papers
Qing Yang is an academic researcher from Wuhan University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Qing Yang include Jiangxi Normal University.
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Papers
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus
Ming-Ming Hu,Qing Yang,Xue-Qin Xie,Chen-Yang Liao,Heng Lin,Tian-Tian Liu,Lei Yin,Hong-Bing Shu +7 more
TL;DR: Findings reveal an essential role for Trim38 in the innate immune response to DNA virus and provide insight into the mechanisms that ensure optimal activation and deactivation of the cGAS-STING pathway.
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iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
TL;DR: It is suggested that iRhom2 is essential for STING activity, as it regulates TRAPβ-mediated translocation and EIF3S5-mediated deubiquitination of STING.
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Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
TL;DR: It is shown that TRIM38 positively regulates MDA5- and RIG-I–mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoylation at K43/K865 and K96/K888, respectively, before and after viral infection.
TRIM38 inhibits TNFα- and IL-1β–triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3
Ming-Ming Hu,Qing Yang,Jing Zhang,Shi-Meng Liu,Yu Zhang,Heng Lin,Zhe-Fu Huang,Yan-Yi Wang,Xiao-Dong Zhang,Bo Zhong,Hong-Bing Shu +10 more
TL;DR: It is concluded that tripartite-motif protein 38 (TRIM38) negatively regulates TNFα- and IL-1β–induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNF- andIL-1 β-induced signaling pathways.
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The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Huan Lian,Ru Zang,Jin Wei,Wen Ye,Ming-Ming Hu,Yun-Da Chen,Xia-Nan Zhang,Yi Guo,Cao-Qi Lei,Qing Yang,Wei-Wei Luo,Shu Li,Hong-Bing Shu +12 more
TL;DR: It is demonstrated that ZCCHC3 is a co‐receptor for RLRs, thereby acting as an important modulator of innate antiviral response.
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