Qing Xu
Duke University
9 Papers
17 Citations
Qing Xu is an academic researcher from Duke University. The author has contributed to research in topics: Microglia & Innate immune system. The author has an hindex of 7, co-authored 9 publications.
Chat about Author
Papers
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
Carol A. Colton,Ryan T. Mott,Hayley J. Sharpe,Qing Xu,William E. Van Nostrand,Michael P. Vitek +5 more
TL;DR: The findings confirmed that treatment of microglia with anti-inflammatory cytokines such as IL-4 and IL-13 induces a gene profile typical of alternative activation similar to that previously observed in peripheral macrophages and suggest that innate immune cells in AD may exhibit a hybrid activation state that includes characteristics of classical and alternative activation.
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
Carol A. Colton,Candice M. Brown,Danielle Cook,Leila K. Needham,Qing Xu,Meggan Czapiga,Ann M. Saunders,Donald E. Schmechel,Karima Rasheed,Michael P. Vitek +9 more
TL;DR: Greater NO production in APOE4 carriers where characteristically high levels of oxidative/nitrosative stress are found in diseases such as AD provides a mechanism that potentially explains the genetic association between APoe4 and human diseases.
144
NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease
Carol A. Colton,Michael P. Vitek,David A. Wink,Qing Xu,Viviana Cantillana,Mary Lou Previti,W E Van Nostrand,J. B. Weinberg,Hana N. Dawson +8 more
TL;DR: It is shown that NO may be a key factor that connects amyloid and tau pathologies and acts at a junction point between β-amyloid peptide levels, neuronal degeneration, caspase-3 activation, and tAU cleavage.
133
The APOE4 genotype alters the response of microglia and macrophages to 17β-estradiol
TL;DR: The data indicate that the APOE genotype may be a critical component in assessing the effectiveness of 17 beta-estradiol's action and may impact the neuroprotective role of 17beta-est radiol and of hormone replacement therapy on brain function when the APoe4 gene is expressed.
56
Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons.
TL;DR: It is shown that CAD cells also express neuronal nitric oxide synthase (nNOS) mRNA and protein and produce readily measurable levels of NO, suggesting that the BH4 levels or access required for nNOS activation is limited in CAD cells.
15