Qing Li
Shandong University
10 Papers
42 Citations
Qing Li is an academic researcher from Shandong University. The author has contributed to research in topics: Somatostatin & Striatum. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Qing Li include McGovern Institute for Brain Research & Peking University.
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Papers
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
Fan Yang,Peng Xiao,Changxiu Qu,Qi Liu,Qi Liu,Liuyang Wang,Zhixin Liu,Qing-tao He,Qing-tao He,Chuan Liu,Jianye Xu,Rui-Rui Li,Meng-Jing Li,Qing Li,Xuzhen Guo,Zhao-ya Yang,Zhao-ya Yang,Dongfang He,Fan Yi,Ke Ruan,Yue-Mao Shen,Xiao Yu,Jin-Peng Sun,Jin-Peng Sun,Jiangyun Wang +24 more
TL;DR: NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation.
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Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells
Haiqiang Dou,Changhe Wang,Xi Wu,Lijun Yao,Xiaoyu Zhang,Sasa Teng,Huadong Xu,Bin Liu,Qihui Wu,Quanfeng Zhang,Meiqin Hu,Yeshi Wang,Li Wang,Yi Wu,Shujiang Shang,Xinjiang Kang,Lianghong Zheng,Jin Zhang,Matthieu Raoux,Jochen Lang,Qing Li,Jing Su,Xiao Yu,Liangyi Chen,Zhuan Zhou +24 more
TL;DR: These findings suggest that depolarisation-induced Ca2+ influx plays dual roles in regulating exocytosis in rat pancreatic beta cells by triggering vesicle fusion and replenishing the vesicles pool to support sustained insulin release.
A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1
Hong-Mei Wang,Jun-hong Dong,Jun-hong Dong,Qing Li,Qiao-Xia Hu,Qiao-Xia Hu,Shanglei Ning,Wenshuai Zheng,Min Cui,Tian-Sheng Chen,Xin Xie,Jin-Peng Sun,Jin-Peng Sun,Xiao Yu +13 more
TL;DR: The role of the adrenergic system in the modulation of somatostatin content and transcription in pancreatic delta cells and the detailed underlying mechanisms of this regulation are investigated.
42
A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions
Qing Li,Min Cui,Fan Yang,Na Li,Baichun Jiang,Zhen Yu,Daolai Zhang,Yi-Jing Wang,Xibin Zhu,Huili Hu,Pei Shan Li,Shang Lei Ning,Si Wang,Haibo Qi,Hechen Song,Dongfang He,Amy Lin,Jingjing Zhang,Feng Liu,Jiajun Zhao,Ling Gao,Fan Yi,Tian Xue,Jin-Peng Sun,Jin-Peng Sun,Yaoqin Gong,Xiao Yu +26 more
TL;DR: An epigenetic regulatory mechanism of &dgr; cell paracrine interactions in which CRL4B-PRC2 complexes, Cav1.2 and AC6 expression fine-tune somatostatin secretion and facilitate glucose homeostasis in pancreatic islets is revealed.
Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo.
Shirong Wang,Wei Yao,Hong-Ping Huang,Bo Zhang,Zuo Panli,Liang Sun,Haiqiang Dou,Qing Li,Xinjiang Kang,Huadong Xu,Meiqin Hu,Mu Jin,Lei Zhang,Yu Mu,Ji-Yun Peng,Claire Xi Zhang,Jiuping Ding,Bao-Ming Li,Zhuan Zhou +18 more
TL;DR: In this paper, the authors examined the effects of vesicle pools on AP-pattern dependent dopamine (DA) overflow and found that the fast-releasable pool (FRP) predominantly contributed to facilitating burst-effect and the FRP played an important role in depressing-burst effect.
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