Qin Wang

TL;DR: It is reported that a careful accounting of methodological differences within the literature can resolve the present lack of consensus on involvement of α2ARs in depression and suggest a selective increase in the density of high-affinity conformational state α2 ARs, which is indicative of enhanced G protein coupling to the receptor.

TL;DR: The present studies demonstrate that no single stretch of sequence in the third intracellular (3i) loop of the α2A adrenergic receptor (α2A-AR) can fully account for its previously described interactions with spinophilin, and suggest that a three-dimensional surface, rather than a linear sequence, provides the basis for these interactions.

TL;DR: Comparing their expression patterns during mouse development revealed that the TnT expression in the developing embryo was not as restricted as that in the adult, and the cTnT transcript was persistently found in the developed bladder, where presumably smooth muscle is present.

TL;DR: This study provides the first evidence to the authors' knowledge that a G protein-coupled receptor, namely, the α2A adrenergic receptor, modulates APP endocytic sorting and promotes Aβ generation through disrupting APP interaction with a Vps10 family protein, sorting-related receptor with A repeat.