Qimin Zhan
Peking Union Medical College
215 Papers
1.3K Citations
Qimin Zhan is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 54, co-authored 186 publications. Previous affiliations of Qimin Zhan include National Institutes of Health.
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Papers
The subcellular distribution and function of MTA1 in cancer differentiation
Jian Liu,Dongkui Xu,Haijuan Wang,Ying Zhang,Yanan Chang,Jinlong Zhang,Jia Wang,Chunxiao Li,Huan Liu,Mei Zhao,Chen Lin,Qimin Zhan,Changzhi Huang,Haili Qian +13 more
TL;DR: The results not only suggest that nuclear MTA1 is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers but also reveal the necessity to differentially examine the functions of nuclear and cytoplasmic MTA1.
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Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization
Zhi-Zhou Shi,Jianwei Liang,Ting Zhan,Bo-Shi Wang,De-Chen Lin,Shu-Guang Liu,Jia-Jie Hao,Hai Yang,Yu Zhang,Qimin Zhan,Kai-Tai Zhang,Ming-Rong Wang +11 more
TL;DR: The data suggest that gain of CPT1A may be a candidate prognostic factor for esophageal squamous cell carcinoma, andarray comparative genomic hybridization on a screening set of 35 tumor samples from ESCC patients confirmed that C PT1A gain provided prognostic information in ESCC.
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Epigenetic changes and functional study of HOXA11 in human gastric cancer
Yingying Cui,Dan Gao,Dan Gao,Enqiang Linghu,Qimin Zhan,Runsheng Chen,Malcolm V. Brock,James G. Herman,Mingzhou Guo +8 more
TL;DR: Restoration of HOXA11 expression reduced cell proliferation, invasion, migration and induced apoptosis and G2/M phase arrest and the presence of methylation was associated with male gender, tumor size, tumor differentiation and lymph node metastasis.
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Role of Smac in Determining the Chemotherapeutic Response of Esophageal Squamous Cell Carcinoma
TL;DR: The data suggested that downregulation of Smac may be a chemoresistance mechanism in ESCC and combined with Smac mimetics with chemotherapeutic agents may have therapeutic benefits for the treatment of esophageal cancer.
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Methylation of CHFR sensitizes esophageal squamous cell cancer to docetaxel and paclitaxel.
Tianyang Yun,Yang Liu,Dan Gao,Enqiang Linghu,Malcolm V. Brock,Dongtao Yin,Qimin Zhan,James G. Herman,Mingzhou Guo +8 more
TL;DR: CHFR is frequently methylated in ESCC and the expression of CHFR is regulated by promoter region methylation, which may re-sensitize chemotherapy resistant in refractory tumors by inducing cell cycle phase re-distribution.