Qiang Wang
University of Pennsylvania
5 Papers
Qiang Wang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genetically modified mouse & Affinity chromatography. The author has an hindex of 5, co-authored 5 publications.
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Papers
The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice.
TL;DR: It is shown that enhanced CNS tropism is restricted to the model in which it was selected, and was not found in nonhuman primates or the other commonly used mouse strain BALB/cJ, and the potential for serious acute toxicity in NHP after systemic administration of high dose of AAV is reported.
367
The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier.
Juliette Hordeaux,Yuan Yuan,Peter Clark,Qiang Wang,R. Alexander Martino,Joshua J. Sims,Peter Bell,Angela Raymond,Angela Raymond,William L. Stanford,William L. Stanford,James M. Wilson +11 more
TL;DR: These studies identify, for the first time, a ligand for this GPI-anchored protein and suggest a role for it in BBB transport that could be hijacked by viruses in natural infections or by gene therapy vectors to treat neurological diseases.
188
Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids
Lili Wang,Peter Bell,Suryanarayan Somanathan,Qiang Wang,Zhenning He,Hongwei Yu,Deirdre McMenamin,Tamara Goode,Roberto Calcedo,James M. Wilson +9 more
TL;DR: A putatively superior hepatotropic capsid is included in this study, but AAVLK03 vectors are not superior to either AAV3B or AAV8, and should be considered for liver-directed gene therapy when administered following, or before, treatment with the serologically distinct clade E vectors.
106
Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin
TL;DR: The substitution of the epitope in AAV8, rh.64R1, and AAV9 with the corresponding epitope of AAV3B resulted in greatly increased affinity to AVB sepharose with no reduction in the vectors’ in vitro potency, suggesting the possibility of vector engineering to yield a universal affinity chromatography purification method for multiple AAV serotypes.
51
Characterization of Adeno-Associated Viral Vector-Mediated Human Factor VIII Gene Therapy in Hemophilia A Mice
Jenny A. Greig,Qiang Wang,Amanda L. Reicherter,Shu-Jen Chen,Alexandra L. Hanlon,Christopher H. Tipper,K. Reed Clark,Samuel C. Wadsworth,Lili Wang,James M. Wilson +9 more
TL;DR: The results of this study, which entailed extensive vector optimization and in vivo testing, demonstrate the significant impact that transcriptional control elements and capsid can have on vector performance.