Qian Zhang
Rockefeller University
105 Papers
168 Citations
Qian Zhang is an academic researcher from Rockefeller University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 28, co-authored 63 publications. Previous affiliations of Qian Zhang include Qatar Airways & Paris Descartes University.
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Papers
Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome
TL;DR: The impaired lymphocyte functions in DIDS patients appear central for disease pathogenesis, as well as large, unique deletions in patients from different families and ethnic backgrounds.
DOCK8 deficiency: DOCK8 deficiency
Helen C. Su,Huie Jing,Qian Zhang +2 more
TL;DR: The clinical features of this disease are related to studies using patients’ cells and a mouse model of Dock8 deficiency, which have revealed how DOCK8 regulates T and B cell numbers and functions, and help to explain how the absence of Dock8 contributes to patients‘ susceptibility to viral, fungal, and bacterial infections.
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Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Qian Zhang,Andrés Pizzorno,Lisa Miorin,Paul Bastard,A Gervais,Tom Le Voyer,Lucy Bizien,Jeremy Manry,Jérémie Rosain,Quentin Philippot,Kelian Goavec,Blandine Padey,Anastasija Cupic,Emilie Laurent,Kahina Saker,M. Vanker,Karita Särekannu,Tamara García-Salum,Marcela Ferrés,Nicole Le Corre,Javier Sánchez-Céspedes,María Balsera-Manzanero,Jordi Carratalà,P Retamar-Gentil,Gabriela Abelenda-Alonso,Adoración Valiente,Pierre Tiberghien,Marie Zins,Stéphanie Debette,Isabelle Meyts,Filomeen Haerynck,Riccardo Castagnoli,Luigi D. Notarangelo,Luis Ignacio Gonzalez-Granado,Nerea Domínguez-Pinilla,Evangelos Andreakos,Vasiliki Triantafyllia,Carlos Rodríguez-Gallego,Jordi Solé-Violán,José Juan Ruiz-Hernández,Felipe Rodríguez de Castro,José Ferreres,M. Luisa Briones,Joost Wauters,Lore Vanderbeke,Simon Feys,Chen Yen Kuo,Wei Li,Chen-Lung Ku,Galit Tal,Amos Etzioni,Suhair Hanna,Thomas Fournet,Jean-Sébastien Casalegno,Grégory Quéromès,Laurent Argaud,Etienne Javouhey,Manuel Rosa-Calatrava,Elisa Cordero,Teresa Aydillo,Rafael A. Medina,Kai Kisand,Anne Puel,Emmanuelle Jouanguy,Laurent Abel,Aurélie Cobat,Sophie Trouillet-Assant,Adolfo García-Sastre,Jean-Laurent Casanova +68 more
TL;DR: In an international cohort of 279 patients with hypoxemic influenza pneumonia, 13 patients were identified with autoantibodies neutralizing IFN-α and/or -ω, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine.
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.
Huie Jing,Qian Zhang,Yu Zhang,Brenna J. Hill,Christopher G. Dove,Erwin W. Gelfand,T. Prescott Atkinson,Gulbu Uzel,Helen F. Matthews,Peter Mustillo,David B. Lewis,Fotini D Kavadas,I. Celine Hanson,Ashish R Kumar,Raif S. Geha,Daniel C. Douek,Steven M. Holland,Alexandra F. Freeman,Helen C. Su +18 more
TL;DR: Observations support the concept that some DOCK8-immunodeficient patients have mutable mosaic genomes that can modulate disease phenotype over time, and only certain combinations of germline mutations supported secondary somatic repair.
DOCK8 is critical for the survival and function of NKT cells
Greg Crawford,Anselm Enders,Uzi Gileadi,Sanda Stankovic,Qian Zhang,Teresa Lambe,Tanya L. Crockford,Helen Lockstone,Alexandra F. Freeman,Peter D. Arkwright,Joanne Smart,Cindy S. Ma,Stuart G. Tangye,Christopher C. Goodnow,Vincenzo Cerundolo,Dale I. Godfrey,Helen C. Su,Katrina L. Randall,Richard J. Cornall +18 more
TL;DR: Impaired NKT cell numbers and function are likely to contribute to the susceptibility of DOCK8-deficient patients to recurrent infections and malignant disease, consistent with the idea that Dock8 mediates survival signals within a specialized niche.
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