15 Papers
397 Citations
Qian Shi is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Pancreatic cancer & Pancreas. The author has an hindex of 14, co-authored 15 publications.
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Papers
•Journal Article
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
TL;DR: It is demonstrated that hypoxia and acidosis contribute to the overexpression of IL-8, which in turn plays an important role in tumor angiogenesis and contributes significantly to the aggressive biology of human pancreatic cancer.
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Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
TL;DR: Data indicated that acidosis transcriptionally and posttranscriptionally regulates VEGF expression, suggesting that an acidic tumor microenvironment contributes to tumor angiogenesis and progression.
264
•Journal Article
Influence of Nitric Oxide Synthase II Gene Disruption on Tumor Growth and Metastasis
TL;DR: The data suggest that disruption of host NOS II expression enhanced the growth and metastasis of NO-sensitive tumor cells but suppressed the metastasis in NO-resistant tumor cells, proposing that host-derived NO may differentially modulate tumor progression.
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Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma.
Xiangdong Le,Qian Shi,Bailiang Wang,Qinghua Xiong,Chao-Nan Qian,Zhihai Peng,Xiang-Cheng Li,Huamei Tang,James L. Abbruzzese,Keping Xie +9 more
TL;DR: The data demonstrated that constitutive NF-kappaB and AP-1 activation contributes to the overexpression of IL-8, which in turn plays an important role in tumor angiogenesis and contribution to the aggressive biology of human pancreatic cancer.
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Regulation of interleukin-8 expression by tumor-associated stress factors.
TL;DR: Understanding the mechanisms of IL-8 expression and regulation will be helpful in designing potential therapeutic modalities targetingIL-8 to control tumor growth and metastasis.
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