Qian Li
University of Kansas
53 Papers
1.2K Citations
Qian Li is an academic researcher from University of Kansas. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 26, co-authored 48 publications. Previous affiliations of Qian Li include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Papers
•Journal Article
Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.
TL;DR: The similarity in time course between fluoxetine-induced reductions in hormone responses to 8-OH-DPAT and the reduction in hypothalamic levels of Gi1 and Gi3 proteins suggests that a reduction in leptin levels ofGi3 and/or Gi1 proteins plays a role in the gradual desensitization of 5-hydroxytryptamine1A receptors induced by fluoxettine.
166
•Journal Article
A Desensitization of Hypothalamic 5-HT1A Receptors by Repeated Injections of Paroxetine: Reduction in the Levels of Gi and Go Proteins and Neuroendocrine Responses, but Not in the Density of 5-HT1AReceptors
TL;DR: Results suggest that blockade of 5-HT uptake sites produces a delayed and gradual desensitization of5-HT1A receptors in the hypothalamus, and reductions in G(i1) or G(o) proteins cannot be excluded as potential mediators of the desensITization of the 5- HT1A receptor systems.
151
Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats
Qian Li,Andrew D. Levy,Theresa M. Cabrera,Mark S. Brownfield,George Battaglia,Louis D. Van de Kar +5 more
TL;DR: It is suggested that chronic, but not acute, exposure to fluoxetine decreases 5-HT1A receptor function, which is not seen in rats chronically exposed to DMI.
141
WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretion.
TL;DR: 8-OH-DPAT stimulates oxytocin, ACTH, and corticosterone but not prolactin secretion via activation of5-HT1A receptors and blockade of 5-HT2A receptors may unmask 8-OH -DPAT simulation of renin secretion through non-5- HT1A receptor mechanisms.
94
•Journal Article
Daily Injections of Fluoxetine Induce Dose-Dependent Desensitization of Hypothalamic 5-HT1A Receptors: Reductions in Neuroendocrine Responses to 8-OH-DPAT and in Levels of Gz and Gi Proteins
D. K. Raap,S. Evans,Francisca Garcia,Qian Li,Nancy A. Muma,W A Wolf,George Battaglia,L.D. Van de Kar +7 more
TL;DR: The results from the present study indicate that fluoxetine-induced desensitization of hypothalamic postsynaptic 5-HT1A receptor systems is dose-dependent and may be caused in part by reductions in the hypothalamic levels of Gz proteins.
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