11 Papers
Qi Sun is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Renal fibrosis & Fibrosis. The author has an hindex of 10, co-authored 11 publications.
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Papers
Sodium-glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice.
Ting Cai,Qingqing Ke,Yi Fang,Ping Wen,Hanzhi Chen,Qi Yuan,Jing Luo,Yu Zhang,Qi Sun,Yunhui Lv,Ke Zen,Lei Jiang,Yang Zhou,Junwei Yang +13 more
TL;DR: It is found that DKD development and progression to renal fibrosis entailed profound changes in proximal tubule metabolism, characterized by a switch from fatty acid utilization to glycolysis and lipid accumulation, which is associated with the increased expression of HIF-1 α .
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Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation.
Qi Yuan,Jiao Miao,Qianqian Yang,Li Fang,Yi Fang,Hao Ding,Yang Zhou,Lei Jiang,Chunsun Dai,Ke Zen,Qi Sun,Junwei Yang +11 more
TL;DR: Mammalian target of rapamycin (mTOR) is identified as a critical regulator of PKM2 during podocyte development, and a stronger glycolytic profile is observed, accompanied by an increased mitochondrial complexity in differentiated podocytes, indicating that mature podocytes boost both gly colysis and mitochondrial metabolism to meet their augmented energy demands.
UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury.
TL;DR: UCP2 attenuates I/R-induced AKI, probably by reducing cell apoptosis through protection of autophagy, and is investigated in an AKI model generated by renal ischemia-reperfusion (I/R).
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UCP2-induced hypoxia promotes lipid accumulation and tubulointerstitial fibrosis during ischemic kidney injury.
Qingqing Ke,Qi Yuan,Nan Qin,Caifeng Shi,Jing Luo,Yi Fang,Lingling Xu,Qi Sun,Ke Zen,Lei Jiang,Yang Zhou,Junwei Yang +11 more
TL;DR: It is demonstrated that mitochondrial uncoupling protein 2 (UCP2) regulates TIF through the stimulation of lipid deposition and extracellular matrix (ECM) accumulation and described a molecular mechanism by which UCP2 regulates HIF-1α stabilization through regulation of mitochondrial respiration and tissue hypoxia during TIF.
Tuberous sclerosis 1 (Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis.
Hongdi Cao,Jing Luo,Yu Zhang,Xiaoming Mao,Ping Wen,Hao Ding,Jing Xu,Qi Sun,Weichun He,Chunsun Dai,Ke Zen,Yang Zhou,Junwei Yang,Lei Jiang +13 more
TL;DR: The findings suggest that Tsc1-associated mTORC1 signaling mediates the progression of kidney interstitial fibrosis by regulating glycolysis in proximal tubular epithelial cells.
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