75 Papers
227 Citations
Qi Hou is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 22, co-authored 72 publications. Previous affiliations of Qi Hou include Medical University of South Carolina.
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Papers
Novel nitric oxide-releasing derivatives of brusatol as anti-inflammatory agents: design, synthesis, biological evaluation, and nitric oxide release studies.
Weibin Tang,Jian-lin Xie,Song Xu,Haining Lv,Mingbao Lin,Shaopeng Yuan,Bai Jinye,Qi Hou,Shi-Shan Yu +8 more
TL;DR: Among them, compound 75 demonstrated inhibition comparable to that of brusatol but were less cytotoxic and showed substantial inhibitory efficacy against chronic obstructive pulmonary disease (COPD)-like inflammation in the mouse model induced by cigarette smoke and lipopolysaccharide.
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Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata.
Yi-Rui Wang,Shao-Wei Han,Ruo-Fei Li,Bao-Song Cui,Xian-Jie Ma,Xinzhu Qi,Qi Hou,Mingbao Lin,Jinye Bai,Shuai Li +9 more
TL;DR: BSP-1 exhibited immunomodulatory effects by increasing the thymus and spleen indices of immunocompromised model mice by more than doubling the number of β‑1,4‑linked d‑mannosyl residues.
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14, 15-epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy
Yunxiao Li,Ganggang Yu,Shaopeng Yuan,Chunting Tan,Jian-lin Xie,Yasi Ding,Puqiao Lian,Lixia Fu,Qi Hou,Bo Xu,Haoyan Wang +10 more
TL;DR: The aim of this study was to explore the effect of 14,15-EET on cigarette smoke condensate (CSC)-induced inflammation in a human bronchial epithelial cell line (Beas-2B), and to determine whether the underlying mechanisms involved in the regulation of Nrf2 through inhibition of autophagy are affected.
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Cyclin D1 Downregulation Contributes to Anticancer Effect of Isorhapontigenin on Human Bladder Cancer Cells
TL;DR: The studies show that isorhapontigenin is an active compound that mediates Gnetum Cleistostachyum's induction of cell-cycle G0–G1 arrest and inhibition of cancer cell anchorage-independent growth through downregulating SP1/cyclin D1 axis in bladder cancer cells.
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Anti-inflammatory Sesquiterpene Derivatives from the Leaves of Tripterygium wilfordii
TL;DR: In an in vitro bioassay, compounds 1, 9, 11, 13, 14, and 18 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages at 5 μM; all compounds were inactive when tested against five human cancer cell lines.
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