Qi Guo
University of Iowa
6 Papers
5 Citations
Qi Guo is an academic researcher from University of Iowa. The author has contributed to research in topics: Chemistry & Formate dehydrogenase. The author has an hindex of 5, co-authored 6 publications.
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Papers
Oscillatory Enzyme Dynamics Revealed by Two-Dimensional Infrared Spectroscopy.
TL;DR: Observations of frequency fluctuations of the azide anion bound to the active site of formate dehydrogenase measured via 2D IR spectroscopy reveal an underdamped oscillatory component to the frequency-frequency correlation function when the azides is bound toThe NAD(+) ternary complex.
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Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase
Philip Pagano,Qi Guo,Chethya Ranasinghe,Evan Schroeder,Kevin C. Robben,Florian Häse,Hepeng Ye,Kyle Wickersham,Alán Aspuru-Guzik,Alán Aspuru-Guzik,Dan Thomas Major,Lokesh Gakhar,Amnon Kohen,Christopher M. Cheatum +13 more
TL;DR: Experimental evidence is provided for a connection between the temperature dependence of KIEs and motions of the active site in an enzyme-catalyzed reaction consistent with activated tunneling models of the hydride transfer reaction.
33
Protein Mass Effects on Formate Dehydrogenase.
Chethya Ranasinghe,Qi Guo,Paul J. Sapienza,Andrew L. Lee,Daniel M. Quinn,Christopher M. Cheatum,Amnon Kohen +6 more
TL;DR: The findings suggest that the mass modulation affected both local, fast, protein vibrations associated with the catalyzed chemistry and the protein's macromolecular electrostatics at slower time scales; that is, both Born-Oppenheimer and non-Born-oppenheimer effects are observed.
24
Chemoenzymatic Synthesis of Ubiquitous Biological Redox Cofactors
TL;DR: This account describes chemoenzymatic syntheses of the isotopically labeled, biologically important redox cofactors: nicotinamide adenine dinucleotide, methylene tetrahydrofolate, and flavin nucleotides.
5
Line shape analysis of two-dimensional infrared spectra
TL;DR: The results show that although all of the methods can, in principle, yield the FFCF under idealized circumstances, under more realistic experimental conditions they behave quite differently, and the centerline slope analysis yields the best compromise between the effects the authors test and is most robust to the distortions that they cause.