Q. May Wang
Eli Lilly and Company
28 Papers
500 Citations
Q. May Wang is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Enzyme & RNA polymerase I. The author has an hindex of 20, co-authored 28 publications. Previous affiliations of Q. May Wang include Wayne State University & Stanford University.
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Papers
Template Requirements for RNA Synthesis by a Recombinant Hepatitis C Virus RNA-Dependent RNA Polymerase
TL;DR: Chimeric molecules composed of DNA and RNA demonstrated that a DNA molecule containing a 3′-terminal ribocytidylate was able to direct RNA synthesis as efficiently as a sequence composed entirely of RNA.
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Identification and Characterization of a Monofunctional Glycosyltransferase from Staphylococcus aureus
Q. May Wang,Robert B. Peery,Robert B. Johnson,William E. Alborn,Wu-Kuang Yeh,Paul L. Skatrud +5 more
TL;DR: The results suggest that this enzyme is natively present in S. aureus cells and that it may play a role in bacterial cell wall biosynthesis.
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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor
Yip Yvonne Yee Mai,Frantz Victor,Jason Eric Lamar,Robert B. Johnson,Q. May Wang,Donna Barket,John I. Glass,Ling Jin,Lifei Liu,Daryl Venable,Mark Wakulchik,Congping Xie,Beverly A. Heinz,Elcira C. Villarreal,Joe Colacino,Nathan Yumibe,Mark Joseph Tebbe,John E. Munroe,Shu-Hui Chen +18 more
TL;DR: The design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles are described.
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P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors
Yip Yvonne Yee Mai,Frantz Victor,Jason Eric Lamar,Robert B. Johnson,Q. May Wang,John I. Glass,Nathan Yumibe,Mark Wakulchik,John E. Munroe,Shu-Hui Chen +9 more
TL;DR: It is found that replacement of the P4 valine as seen in 1a with cyclohexylglycine (Chg) resulted in the discovery of 5a, 5c, and 5e endowed with improved cellular activity in comparison to 1a.
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Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis
Vincent J.-P. Lévêque,Robert B. Johnson,Stephen Parsons,Jianxin Ren,Congping Xie,Faming Zhang,Q. May Wang +6 more
TL;DR: Results provide not only direct experimental insights into the role of the C-terminal tail of HCV NS5B polymerase but also a working model for the RNA synthesis mechanism employed by HCV and related viruses.
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