Prem Kumarathasan
Health Canada
45 Papers
198 Citations
Prem Kumarathasan is an academic researcher from Health Canada. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 21, co-authored 36 publications. Previous affiliations of Prem Kumarathasan include North Dakota State University.
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Papers
Mapping acute systemic effects of inhaled particulate matter and ozone: multiorgan gene expression and glucocorticoid activity.
Errol M. Thomson,Djordje Vladisavljevic,Susantha Mohottalage,Prem Kumarathasan,Renaud Vincent +4 more
TL;DR: Investigation of gene profiles in the lungs, heart, liver, kidney, spleen, cerebral hemisphere, and pituitary of male Fischer-344 rats suggests chronic activation and inappropriate regulation of the hypothalamic-pituitary-adrenal axis are associated with adverse neurobehavioral, metabolic, immune, developmental, and cardiovascular effects.
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Regulation of Promoter-CAT Stress Genes in HepG2 Cells by Suspensions of Particles from Ambient Air
Renaud Vincent,Patrick Goegan,Gala Johnson,Jeffrey R. Brook,Prem Kumarathasan,Léo Bouthillier,Richard T. Burnett +6 more
TL;DR: The results indicate that bioavailable chemical species in the unfractionated particles can directly and quantitatively induce xenobiotic, metal, and stress-dependent responses in a target cell model, resulting in patterns of gene induction consistent with the chemical compositions of the environmental materials.
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Cytotoxic and Inflammatory Potential of Size-Fractionated Particulate Matter Collected Repeatedly Within a Small Urban Area
Errol M. Thomson,Dalibor Breznan,Subramanian Karthikeyan,Christine MacKinnon-Roy,Jean-Pierre Charland,Ewa Dabek-Zlotorzynska,Valbona Celo,Prem Kumarathasan,Jeffrey R. Brook,Renaud Vincent +9 more
TL;DR: The data show that particle potency and composition can exhibit significant temporal variation in relation to source contributions; 2) sources may differentially impact the potency of specific size fractions; and 3) particle constituents, notably metals and endotoxin, may elicit distinct biological responses.
An optimized protein in-gel digest method for reliable proteome characterization by MALDI-TOF-MS analysis
TL;DR: Human lung epithelial cells were used as a model to develop a reliable proteome characterization method by peptide mass fingerprinting (PMF), yielding reliable, unambiguous protein identification with femtomol protein sensitivity by Autoflex MALDI-TOF-MS.
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New approach to the simultaneous analysis of catecholamines and tyrosines in biological fluids.
Prem Kumarathasan,Renaud Vincent +1 more
TL;DR: New high-performance liquid chromatographic methods with amperometric-CoulArray detection were developed for simultaneous analyses of norepinephrine, epinephrine, L-DOPA, dopamine, 3-nitrotyrosine, m-, o-, and p-tyrosines.
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