Preethi Badrinarayan
Indian Institute of Chemical Technology
11 Papers
77 Citations
Preethi Badrinarayan is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Virtual screening & Protein Data Bank. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Preethi Badrinarayan include Swami Ramanand Teerth Marathwada University.
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Papers
Virtual High Throughput Screening in New Lead Identification
TL;DR: This review presents a critical account on the relevance of molecular modelling approaches in general, lead optimization and virtual screening methods in particular for new lead identification, as it is an extremely important measure for the reliability of scoring function.
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Virtual screening filters for the design of type II p38 MAP kinase inhibitors: a fragment based library generation approach.
TL;DR: Target specific virtual screening filters can be easily developed for other kinases based on this strategy to retrieve target selective compounds.
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Rational Approaches Towards Lead Optimization of Kinase Inhibitors: The Issue of Specificity
Preethi Badrinarayan,G. Sastry +1 more
TL;DR: The probable hot-spots in kinases having a propensity to bring in specificity have been delineated and special emphasis on the design of type II inhibitors with increased specificity from existing type I using fragment tailoring approach is focused on.
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Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.
TL;DR: Seven major non-covalent interactions and their complementary sites in AK capable of rendering specificity have been prioritized for the design of different classes of inhibitors.
Targeting progesterone metabolism in breast cancer with l-proline derived new 14-azasteroids.
Jyotsana Singh,Ritesh Singh,Preeti Gupta,Smita Rai,Asha Ganesher,Preethi Badrinarayan,G. Narahari Sastry,Rituraj Konwar,Rituraj Konwar,Gautam Panda,Gautam Panda +10 more
TL;DR: The proof of concept and generation of new leads for additional targeting of breast cancer via progesterone signalling are established and data suggests that compound 3b binds and down regulates of 5α-reductase by specifically inhibiting production of progestersone metabolites that are capable of promoting breast cancer proliferation, epithelial mesenchymal transition and migration.
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