Pratik S. Randeria
Northwestern University
8 Papers
1 Citations
Pratik S. Randeria is an academic researcher from Northwestern University. The author has contributed to research in topics: Spherical nucleic acid & Small nuclear RNA. The author has an hindex of 7, co-authored 8 publications.
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Papers
Multiplexed Nanoflares: mRNA Detection in Live Cells
Andrew E. Prigodich,Pratik S. Randeria,William E. Briley,Nathaniel Kim,Weston L. Daniel,David A. Giljohann,Chad A. Mirkin +6 more
TL;DR: The multiplexed nanoflare is a nanoparticle agent that is capable of simultaneously detecting two distinct mRNA targets inside a living cell, and one of the targets can be used as an internal control, improving detection by accounting for cell-to-cell variations in nanoparticle uptake and background.
siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown
Pratik S. Randeria,Mark A. Seeger,Xiao Qi Wang,Heather M. Wilson,Desmond Shipp,Chad A. Mirkin,Amy S. Paller +6 more
TL;DR: This work introduces a previously unidentified approach to treating diabetic wound healing by using topically delivered spherical nucleic acids to effect the knockdown of ganglioside-monosialic acid 3 (GM3) synthase, a mediator of impaired wound healing, in type 2 diabetic mice and validates the critical role of GM3 in diabetic wounds healing.
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Quantification and real-time tracking of RNA in live cells using Sticky-flares.
TL;DR: A novel spherical nucleic acid (SNA) gold nanoparticle conjugate, termed the Sticky-flare, which enables facile quantification of RNA expression in live cells and spatiotemporal analysis of RNA transport and localization and gains a more complete picture or RNA function than any analytical technique to date.
106
Patent
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
Chad A. Mirkin,William E. Briley,Pratik S. Randeria,Nathaniel Kim +3 more
- 04 Nov 2014
TL;DR: In this article, the authors proposed methods of detecting and tracking a target molecule using a nanoparticle wherein the nanoparticle comprises a polynucleotide that can specifically associate with the target molecule, and wherein the association results in a change in a detectable marker that can be measured after association.
1
What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids
Pratik S. Randeria,Matthew R. Jones,Kevin L. Kohlstedt,Resham J. Banga,Monica Olvera de la Cruz,George C. Schatz,Chad A. Mirkin +6 more
TL;DR: The hybridization of free oligonucleotides to densely packed, oriented arrays of DNA modifying the surfaces of spherical nucleic acid (SNA)-gold nanoparticle conjugates occurs with negative cooperativity andThermodynamic quantification of this behavior reveals a 3 orders of magnitude decrease in the binding constant.