Pseudoglandular schwannoma (PGS) is a rare morphological variant of benign schwannoma. PGS is quite distinct from the somewhat better characterized glandular schwannoma variant. PGS is characterized by the presence of gland-like structures lined with pseudocolumnar or cuboidal-like neoplastic Schwann cells lining variably sized cystic space cells. Herein, we describe a rare case of PGS in a 17-year-old adolescent boy with a neck mass 8.5 cm in diameter present for 2 years with a recent increase in size. Fine-needle aspiration (FNA) demonstrated abundant rhabdoid-like cuboidal cells, plasmacytoid cells, binucleation, clusters of round to oval cells with scant cytoplasm, and a lack of stromal cells with spindle or oval nuclei. These findings were challenging and were reminiscent of alveolar rhabdomyosarcoma on FNA. Magnetic resonance imaging was also suggestive of malignancy. However, the histologic picture and the immunohistochemical analysis of the resected mass were consisted with PGS. The numerous rhabdoid-like cuboidal neoplastic Schwann cells with a plasmacytoid appearance, paving cystic spaces, and the lack of blunt-ended proliferating stromal cells on smears mimicked alveolar rhabdomyosarcoma on FNA. To our knowledge, cytological features of PGS have not been previously reported. This is the first published report of an unusual PGS case located in the neck region causing a diagnostic dilemma on cytology.

Pseudoglandular schwannoma mimicking alveolar rhabdomyosarcoma: A diagnostic challenge on fine-needle cytology.

Ancient Schwannoma is a type of peripheral neurogenic tumor formed by the Schwann cells presenting mainly as a benign and asymptomatic lesion. The neurilemmoma tumor appears in different sites and, in cases of cervical location, can mimic a carotid body tumor. Herein we describe a clinical case of a 51-year-old woman with latero-cervical swelling. A contrast-enhanced computed tomography scan revealed a classical wineglass image mimicking a carotid body tumor. During surgery the tumor appeared connected to the cervical sympathetic trunk without carotid involvement. The histological exam confirmed the nature of the mass which consisted of an ancient schwannoma. A subsequent systematic review of the literature on ancient schwannoma incidence and treatment confirms it being a benign and rare lesion primarily treatable with open surgery. KEY WORDS: Ancient Schwannoma, Carotid body tumor, Carotid artery, Vascular surgery.

Ancient schwannoma mimicking a carotid body tumor A case report and review of the literature.

Ancient schwannoma of the nose: Case report and literature review

Introduction. Schwannoma or neurilemmoma is a benign tumor of the nerve sheath originating from the Schwann cells. Localization in abdominal wall is rare. Schwannomas usually manifest themselves as slow-growing asymptomatic tumors. Symptomatology depends on the location, the involved nerve and the size of the tumor. Case report. We present a 43-year-old female patient with a schwannoma localized in the right hypochondriac region. Diagnostic procedures included ultra-sound with color Doppler (US), high-resolution magnetic resonance imaging (MRI), and histopathological examinations (HP). US showed a solid, well-circumscribed mass, with a whorled, echogenic internal architecture in the anterior abdominal wall. MRI revealed an oval, well-circumscribed, heterogeneous, 3 ? 2.5 ? 2.5 centimeters large fusiform mass. T1- weighted imaging presented low signal intensity, while T2- weighted image showed heterogeneously high signal intensity. The lesion was completely removed. After pathohistological analysis with standard and immunohistochemical methods of coloring, the diagnosis of the schwannoma was confirmed. Conclusion. Schwannoma as a slow-growing tumor, which is often without clinical manifestations, may cause a delay in diagnosis and treatment. Clinical presentation of a schwannoma is indolent and non-specific. Diagnosis of this tumor requires a multidisciplinary and interdisciplinary approach. MR is a useful and highly specific method for the verification of peripheral nerve sheath tumors. A HP analysis confirmed definitive diagnosis of the lesion.

/pdf/schwannoma-of-the-abdominal-wall-diagnostic-chalenge-20n1677x70.pdf

Schwannoma of the abdominal wall - diagnostic chalenge

Ancient schwannomas are rare benign encapsulated tumors of long standing duration. These tumors are usually solitary and may grow to a large size before detection of notable degenerative changes. The term “ancient schwannoma” is used to describe a schwannoma that has undergone changes such as relative loss of Antoni Type A tissue, perivascular hyalinization, calcification, cystic necrosis, hemorrhage and the presence of degenerative nuclear changes that may be misinterpreted as sarcomatous change. We report a case of ancient schwannoma in the left side neck.

Ancient schwannoma of neck masquedring as sarcoma

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Ancient schwannoma of neck masquedring as sarcoma