Prasanna K. Devaraneni
Oregon Health & Science University
11 Papers
43 Citations
Prasanna K. Devaraneni is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Sulfonylurea receptor & Potassium channel. The author has an hindex of 9, co-authored 11 publications.
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Papers
Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state.
Prasanna K. Devaraneni,Alexander G. Komarov,Corey A. Costantino,Jordan J. Devereaux,Kimberly Matulef,Francis I. Valiyaveetil +5 more
TL;DR: This study suggests that the constricted conformation of the selectivity filter is not the C-type inactivated state in a K+ channel, and develops a modular approach in which chemical synthesis is limited to theSelectivity filter whereas the rest of the protein is obtained by recombinant means.
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Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.
TL;DR: Studies to date aimed at understanding the mechanisms by which mutations impair channel biogenesis and trafficking and the mechanism by which pharmacological ligands overcome channel trafficking defects are reviewed are reviewed.
Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.
Gregory M. Martin,Emily A. Rex,Prasanna K. Devaraneni,Jerod S. Denton,Kara E. Boodhansingh,Diva D. DeLeón,Charles A. Stanley,Show Ling Shyng +7 more
TL;DR: This study expands the list of KATP channel trafficking mutations whose function can be recovered by pharmacological ligands and provides further insight into the structural mechanism by which channel inhibitors correct channel biogenesis and trafficking defects.
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Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.
TL;DR: These findings reveal a converging pharmacological chaperoning mechanism wherein glibenclamide and carbamazepine stabilize the heteromeric subunit interface critical for channel biogenesis to overcome defective biogenesis caused by mutations in individual subunits.
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Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP
Qing Zhou,Pei Chun Chen,Pei Chun Chen,Prasanna K. Devaraneni,Gregory M. Martin,Erik M. Olson,Show Ling Shyng +6 more
TL;DR: Striking similarities between carbamazepine and sulfonylureas in their effects on KATP channel biogenesis and gating are revealed and suggest that the 2 classes of drugs may act via a converging mechanism.
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