Pranas Grigaitis
VU University Amsterdam
16 Papers
64 Citations
Pranas Grigaitis is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Biology & Saccharomyces cerevisiae. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Pranas Grigaitis include Heidelberg University & Vilnius University.
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Papers
Transcription activation is enhanced by multivalent interactions independent of liquid-liquid phase separation
TL;DR: In this paper, the authors dissected the mechanism of transcription activation at a reporter gene array with real-time single-cell fluorescence microscopy readouts and found that the phase separation propensity of the activation domain correlates with high transcription activation capacity by increasing binding site occupancy, residence time and the recruitment of co-activators.
Transcription activation is enhanced by multivalent interactions independent of phase separation
TL;DR: In this article, the authors dissected transcription activation by comparing different synthetic TFs at a reporter gene array with real-time single-cell fluorescence microscopy readouts, and concluded that multivalent AD mediated interactions increase the transcription activation capacity of a TF by stabilizing chromatin binding and mediating the recruitment of co-activators independent of phase separation.
Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Ibrahim E. Elsemman,Angelica Rodriguez Prado,Pranas Grigaitis,Manuel Garcia-Albornoz,Victoria M. Harman,Stephen W. Holman,Johan H. van Heerden,Frank J. Bruggeman,Markus M.M. Bisschops,Nikolaus Sonnenschein,Simon Hubbard,Robert Prenton Beynon,Pascale Daran-Lapujade,Jens Nielsen,Bas Teusink +14 more
TL;DR: In this paper , the authors present a comprehensive metabolic model of the yeast cell, based on its full metabolic reaction network extended with protein synthesis and degradation reactions, which predicts metabolic fluxes and corresponding protein expression by constraining compartment-specific protein pools and maximising growth rate.
The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116
Daiva Dabkeviciene,Violeta Jonusiene,Vilmante Zitkute,Egle Zalyte,Pranas Grigaitis,Vida Kirveliene,Ausra Sasnauskiene +6 more
TL;DR: Investigation of the expression of CXCL8–CXCR1/2 pathway, its impact on cell proliferation and cytokine expression in human colorectal carcinoma HCT116 cells, and their chemotherapy-resistant subline found that IL-1 alpha stimulates the production of CxCL8 throughIL-1 receptor signaling.
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Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Ibrahim E. Elsemman,Ibrahim E. Elsemman,Rodrigues Prado A,Pranas Grigaitis,Garcia Albornoz M,Harman,Stephen W. Holman,van Heerden J,Frank J. Bruggeman,Bisschops Mmm,Nikolaus Sonnenschein,Simon J. Hubbard,Robert J. Beynon,Pascale Daran-Lapujade,Jens Nielsen,Jens Nielsen,Bas Teusink +16 more
TL;DR: In this article, the authors developed a comprehensive metabolic model of the yeast cell, based on its full metabolic reaction network extended with protein synthesis and degradation reactions (16304 reactions in total).