Prafull Kumar Singh
Indian Veterinary Research Institute
25 Papers
73 Citations
Prafull Kumar Singh is an academic researcher from Indian Veterinary Research Institute. The author has contributed to research in topics: Apoptosis & HeLa. The author has an hindex of 10, co-authored 22 publications. Previous affiliations of Prafull Kumar Singh include University of Freiburg & University Medical Center Freiburg.
Chat about Author
Papers
•Journal Article
Oncolytic viruses & their specific targeting to tumour cells
TL;DR: In this review, the mechanisms by which oncolytic viruses kill the tumour cells have been discussed as also the development made in virotherapy for cancer treatment with emphasis on their tumour specific targeting.
98
How useful are clinical liver function tests in in vitro human hepatotoxicity assays
TL;DR: Urea measurement proofed to be robust in predicting hepatocellular stress; therefore it should be included in preclinical testing strategies for an improved prediction of DILI.
34
Canine Parvovirus Type 2a (CPV-2a)-Induced Apoptosis in MDCK Involves Both Extrinsic and Intrinsic Pathways
Juwar Doley,Lakshya Veer Singh,G.V.P.P.S. Ravi Kumar,Aditya Prasad Sahoo,Lovleen Saxena,Uttara Chaturvedi,Shikha Saxena,Rajiv Kumar,Prafull Kumar Singh,R. S. Rajmani,Lakshman Santra,S. K. Palia,Sangeeta Tiwari,D. R. Harish,Arvind Kumar,G. S. Desai,Smita Gupta,Shishir Kumar Gupta,Ashok K. Tiwari +18 more
TL;DR: The apoptotic potential of the “new CPV-2a” in MDCK cells is evaluated and the mechanism of the induction of apoptosis is elucidated and caspase dependent involving extrinsic, intrinsic, and endoplasmic reticulum pathways.
28
Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim
Prafull Kumar Singh,Aristomenis Roukounakis,Arnim Weber,Kushal Kumar Das,Bénédicte Sohm,Andreas Villunger,Ana J. García-Sáez,Georg Häcker +7 more
TL;DR: The results suggest that Bmf overexpression-induced Bim degradation is not due to the displacement of Bim from anti-apoptotic Bcl-2 proteins but a direct consequence of the modulation of BIM–DYNLL association.
HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
R. S. Rajmani,Ravi Kumar Gandham,Shishir Kumar Gupta,Aditya Prasad Sahoo,Prafull Kumar Singh,Rajiv Kumar,Shikha Saxena,Uttara Chaturvedi,Ashok K. Tiwari +8 more
TL;DR: The results of the study indicate that HN protein causes apoptosis in HeLa cells, as observed by the translocation of Phosphatidylserine, activation of caspases, cleavage of poly (ADP-ribose) polymerase (PARP), and DNA fragmentation.
16