Pooja Mohan
University of British Columbia
10 Papers
197 Citations
Pooja Mohan is an academic researcher from University of British Columbia. The author has contributed to research in topics: Centrosome & Microtubule. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Pooja Mohan include Family Research Institute.
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Papers
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
Christopher A. Maxwell,Javier Benitez,Laia Gómez-Baldó,Ana Osorio,Núria Bonifaci,Ricardo Fernandez-Ramires,Sylvain V. Costes,Elisabet Guinó,Helen Chen,G Evans,Pooja Mohan,Isabel Catala,Anna Petit,Helena Aguilar,Alberto Villanueva,Alvaro Aytes,Jordi Serra-Musach,Gad Rennert,Flavio Lejbkowicz,Paolo Peterlongo,Siranoush Manoukian,Bernard Peissel,Carla B. Ripamonti,Bernardo Bonanni,Alessandra Viel,Anna Allavena,Loris Bernard,Paolo Radice,Eitan Friedman,Bella Kaufman,Yael Laitman,Maya Dubrovsky,Roni Milgrom,Anna Jakubowska,Cezary Cybulski,Bohdan Górski,Katarzyna Jaworska,Katarzyna Durda,Grzegorz Sukiennicki,Jan Lubinski,Yin Yao Shugart,Susan M. Domchek,Richard Letrero,Barbara L. Weber,Frans B. L. Hogervorst,Matti A. Rookus,J. Margriet Collée,Peter Devilee,Marjolijn J. L. Ligtenberg,Rob B. van der Luijt,Cora M. Aalfs,Quinten Waisfisz,Juul T. Wijnen,Cornelis E. P. van Roozendaal,Douglas F. Easton,Susan Peock,Margaret Cook,Clare Oliver,Debra Frost,Patricia Harrington,D. Gareth Evans,Fiona Lalloo,Rosalind A. Eeles,Louise Izatt,Carol Chu,Diana Eccles,Fiona Douglas,Carole Brewer,Heli Nevanlinna,Tuomas Heikkinen,Fergus J. Couch,Noralane M. Lindor,Xianshu Wang,Andrew K. Godwin,Maria A. Caligo,Grazia Lombardi,Niklas Loman,Per Karlsson,Hans Ehrencrona,Anna von Wachenfeldt,Rosa B. Barkardottir,Ute Hamann,Muhammad Usman Rashid,Adriana Lasa,Trinidad Caldés,Raquel Andrés,Michael Schmitt,Volker Assmann,Kristen N. Stevens,Kenneth Offit,Joao Curado,Hagen Tilgner,Roderic Guigó,Gemma Aiza,Joan Brunet,Joan Castellsague,Griselda Martrat,Ander Urruticoechea,Ignacio Blanco,Laima Tihomirova,David E. Goldgar,Saundra S. Buys,Esther M. John,Alexander Miron,Melissa C. Southey,Mary B. Daly,Rita K. Schmutzler,Barbara Wappenschmidt,Alfons Meindl,Norbert Arnold,Helmut Deissler,Raymonda Varon-Mateeva,Christian Sutter,Dieter Niederacher,Evgeny Imyamitov,Olga M. Sinilnikova,Dominique Stoppa-Lyonne,Sylvie Mazoyer,Carole Verny-Pierre,Laurent Castera,Antoine De Pauw,Yves-Jean Bignon,Nancy Uhrhammer,Jean-Philippe Peyrat,Philippe Vennin,Sandra Fert Ferrer,Marie-Agnès Collonge-Rame,Isabelle Mortemousque,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,Sue Healey,Mary Helen Barcellos-Hoff,Marc Vidal,Stephen B. Gruber,Conxi Lázaro,Gabriel Capellá,Lesley McGuffog,Katherine L. Nathanson,Antonis C. Antoniou,Georgia Chenevix-Trench,Markus C. Fleisch,Victor Moreno,Miguel Angel Pujana +143 more
TL;DR: Cell biological analysis of the protein product suggests a function in regulating development of the mammary gland and genetic analysis identifies the HMMR gene as a modifier of the breast cancer risk associated with BRCA1 gene mutation.
Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.
Helen Chen,Pooja Mohan,Jihong Jiang,Oksana Nemirovsky,Daniel He,Markus C. Fleisch,Dieter Niederacher,Linda M. Pilarski,C. James Lim,Christopher A. Maxwell +9 more
TL;DR: RHAMM is identified as a critical regulator for Aurora kinase A signaling and RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways.
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Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A.
Tony L.H. Chu,Marisa Connell,Lixin Zhou,Zhengcheng He,Jennifer R. Won,Helen Chen,Seyed M.R. Rahavi,Pooja Mohan,Oksana Nemirovsky,Abbas Fotovati,Miguel Angel Pujana,Gregor S. D. Reid,Torsten O. Nielsen,Nelly Panté,Christopher A. Maxwell +14 more
TL;DR: Together, these data demonstrate an Aurora-A/TPX2/HMMR molecular axis that intersects cell-cycle progression and cell migration, which has the potential to influence the survival of patients with ER-negative breast tumors.
Novel Drugs for the Management of Hepatic Encephalopathy: Still a Long Journey to Travel.
Siddheesh Rajpurohit,Balaji Musunuri,Shailesh,Pooja Mohan,Shiran Shetty +4 more
TL;DR: In this article , the authors discuss the novel therapeutic targets for HE in liver cirrhosis patients with supporting clinical trial data and discuss their clinical use due to the presence of major drawbacks in their study design, sample size, safety profile, bias and heterogenicity.
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Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling
Isidre Ferrer,Pooja Mohan,Helen Chen,Joan Castellsague,Laia Gómez-Baldó,Marga Carmona,Nadia García,Helena Aguilar,Jihong Jiang,Margaretha A. Skowron,Mark Nellist,Israel Ampuero,Antonio Russi,Conxi Lázaro,Christopher A. Maxwell,Miguel Angel Pujana +15 more
TL;DR: The hypothesis that loss of TSC2 expression can alter microtubule organization and dynamics, which, in turn, deregulate cell division and potentially impair neuronal differentiation is supported.