Pingyu Zeng
Indiana University
5 Papers
63 Citations
Pingyu Zeng is an academic researcher from Indiana University. The author has contributed to research in topics: MAPK/ERK pathway & Signal transduction. The author has an hindex of 4, co-authored 5 publications.
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Papers
RNA interference (RNAi) for extracellular signal-regulated kinase 1 (ERK1) alone is sufficient to suppress cell viability in ovarian cancer cells
TL;DR: Treatment of ovarian cancer cells with small inhibitory RNAs directed against ERK1 and ERK2 leads to the induction of apoptosis and necrosis by four hours following treatment, and it is found that primary, non-malignant ovarian cells do not respond similarly to ERK siRNA treatment and that these cells fail to die following treatment.
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Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells.
TL;DR: It is concluded, that members of the G HRH family of peptides differentially activate multiple intracellular signaling pathways and suggest that the biologic actions of GHRH may be far more diverse than previously thought.
9
Development of a transgenic mouse that overexpresses a novel product of the growth hormone-releasing hormone gene.
Shijing Fang,Rosemary Steinmetz,Denise Walker King,Pingyu Zeng,Catherine M. Vogelweid,Scott Cooper,Giao Hangcoc,Hal E. Broxmeyer,Ora H. Pescovitz +8 more
TL;DR: Northern blot and RT-PCR were used to demonstrate ubiquitous expression of the transgene in tissues from GHRH-RP Tg animals, which had significantly increased cell cycling for granulocyte-macrophage, erythroid, and hematopoiesis.
Mechanisms Regulating the Constitutive Activation of the ERK Signaling Pathway in Ovarian Cancer and the Effect of RNAi for ERK1/2 on Cancer Cell Proliferation
Rosemary Steinmetz,Heather A. Wagoner,Pingyu Zeng,Jessica R. Hammond,Tamara S. Hannon,Justin L. Meyers,Ora H. Pescovitz +6 more
- 01 Jan 2004
4
Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation.
Rosemary Steinmetz,Heather A. Wagoner,Pingyu Zeng,Jessica R. Hammond,Tamara S. Hannon,Justin L. Meyers,Ora H. Pescovitz +6 more
TL;DR: Evidence is provided that the ERK pathway plays a major role in ovarian cancer pathogenesis and that down-regulation of this master signaling pathway is highly effective for the inhibition of ovarian tumor growth.