Pingping Li
5 Papers
Pingping Li is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 4 publications.
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Papers
DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy
Xiaoyin Ma,Shuxian Han,You-Xia Liu,Yu Chen,Pingping Li,Xiaoyan Liu,Lifu Chang,Yi Chen,Feng Chen,Qian Hou,Ling Hou +10 more
TL;DR: In this article , the expression of death-associated protein-like 1 (DAPL1) is downregulated in PVR membranes and that deficiency promotes EMT in RPE cells in mice.
Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway
Yudong Yang,Chi Zhang,Yixuan Song,Yawen Li,Pingping Li,Min Huang,Fei-Long Meng,Mingliang Zhang +7 more
TL;DR: The role of the canonical transforming growth factor-β pathway in gene editing is revealed and ABEs are equip with precise chemical control and facilitated the editing of disease-associated genes in vitro and in vivo.
Carbon ions trigger DNA damage response to overcome radioresistance by regulating β-catenin signaling in quiescent HeLa cells.
TL;DR: In this article , the functional role and underlying mechanism of carbon ions in overcoming the radioresistance of quiescent cervical cancer HeLa cells were determined, and three strategies for eradicating quiescence cancer cells using high-linear energy transfer (LET) carbon ions were proposed: direct cell death through complex DNA damage; apoptosis via an enhanced mitochondria-mediated intrinsic pathway; forced re-entry into the cell cycle, thereby improving their susceptibility to ionizing radiation.
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DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features
Xiaoyin Ma,Huaicheng Chen,Shu-yu Jian,Junhao He,You-Xia Liu,Shuxian Han,Lifu Chang,Pingping Li,Yi Chen,Xiaoyan Liu,Xiaojuan Hu,Yu Chen,Ling Hou +12 more
TL;DR: In this paper , the authors showed that deficiencies in Dapl1, a susceptibility gene for human AMD, impair the antioxidant capacity of the RPE and lead to age-related retinal degeneration in the 18-month-old mice homozygous for a partial deletion of Dapl 1.