Ping Xia
Children's Hospital Los Angeles
7 Papers
58 Citations
Ping Xia is an academic researcher from Children's Hospital Los Angeles. The author has contributed to research in topics: Genetic enhancement & Bone marrow. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Ping Xia include University of Bordeaux & City of Hope National Medical Center.
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Papers
Successful correction of the human β-thalassemia major phenotype using a lentiviral vector
Geetha Puthenveetil,Jessica Scholes,Jessica Scholes,Denysha Carbonell,Denysha Carbonell,Naveen Qureshi,Naveen Qureshi,Ping Xia,Ping Xia,Licheng Zeng,Licheng Zeng,Shulian Li,Shulian Li,Ying Yu,Ying Yu,Alan L Hiti,Alan L Hiti,Jiing-Kuan Yee,Jiing-Kuan Yee,Punam Malik,Punam Malik +20 more
TL;DR: The results show genetic modification of primitive progenitor cells with correction of the human thalassemia major phenotype with restoration of effective erythropoiesis and reversal of the abnormally elevated apoptosis that characterizes beta-thalassemia.
207
High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors.
François Moreau-Gaudry,Ping Xia,Ping Xia,Gang Jiang,Gang Jiang,Natalya Perelman,Gerhard Bauer,James Ellis,Kathy H. Surinya,Kathy H. Surinya,Fulvio Mavilio,Che Kun Shen,Punam Malik,Punam Malik,Punam Malik +14 more
TL;DR: Modular use of erythroid-specific enhancers/promoters and WPRE in SIN-lentiviral vectors led to identification of high-titer, stably transmitted vectors with high-level erystroid- specific expression for gene therapy of red cell diseases.
132
Improved Human β-globin Expression from Self-inactivating Lentiviral Vectors Carrying the Chicken Hypersensitive Site-4 (cHS4) Insulator Element
Paritha Arumugam,Jessica Scholes,Natalya Perelman,Ping Xia,Jiing-Kuan Yee,Punam Malik,Punam Malik,Punam Malik +7 more
TL;DR: In this article, the chicken hypersensitive site-4 (cHS4) chromatin insulator element was used to design a lentiviral vector for β-thalassemia major (β-TM) gene therapy.
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Gene therapy of a mouse model of protoporphyria with a self-inactivating erythroid-specific lentiviral vector without preselection.
Emmanuel Richard,Manuel Mendez,Frédéric Mazurier,Carine Morel,Pierre Costet,Ping Xia,Antonio Fontanellas,Fabien Géronimi,Muriel Cario-André,Laurence Taine,Cécile Ged,Punam Malik,Hubert de Verneuil,François Moreau-Gaudry +13 more
TL;DR: A self-inactivating lentiviral vector containing human ferrochelatase cDNA driven by the human ankyrin-1/beta-globin HS-40 chimeric erythroid promoter/enhancer is developed, resulting in effective gene therapy of primary and secondary recipient EPP mice without any selectable system.
61
Self-inactivating lentiviral vectors resist proviral methylation but do not confer position-independent expression in hematopoietic stem cells.
Azim Mohamedali,François Moreau-Gaudry,Emmanuel Richard,Emmanuel Richard,Ping Xia,Jan A. Nolta,Punam Malik +6 more
TL;DR: Long-term expression, methylation, and position effects (PE) from two GFP-encoding SIN-LV containing erythroid enhancers and the human ankyrin-1 promoter using the murine secondary bone marrow (BM) transplant assay show that erythyroid-specific Sin-LV express long term and resist methylation-associated proviral silencing, but may require additional elements to confer position-independent expression.
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