Ping Sun
Guangzhou Medical University
9 Papers
28 Citations
Ping Sun is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Inflammasome & Neuraminidase. The author has an hindex of 3, co-authored 9 publications.
Chat about Author
Papers
Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation.
TL;DR: This study identified disulfiram (DSF), an old marketed drug as a treatment for alcoholism, could effectively inhibit NLRP3 inflammasome activation and suppress pyroptotic cell death and showed remarkable therapeutic effects on the LPS-induced peritoneal inflammation and MSU-induced gouty inflammation.
88
Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses
Xin Zhao,Xin Zhao,Xin Zhao,Runfeng Li,Yang Zhou,Mengjie Xiao,Mengjie Xiao,Chunlong Ma,Zhongjin Yang,Shaogao Zeng,Qiuling Du,Chunguang Yang,Haiming Jiang,Yanmei Hu,Kefeng Wang,Chris Ka Pun Mok,Chris Ka Pun Mok,Ping Sun,Jianghong Dong,Wei Cui,Jun Wang,Yaoquan Tu,Zifeng Yang,Wenhui Hu,Wenhui Hu +24 more
TL;DR: A structure-activity relationship (SAR) of pinanamine-based antivirals is explored and a potent inhibitor M090 is discovered against amantadine-resistant viruses, including the 2009 H1N1 pandemic strains, and oseltamivir- resistant viruses.
Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities
Cheng Zhang,Hu Yue,Ping Sun,Lei Hua,Shuli Liang,Yitao Ou,Dan Wu,Xinyi Wu,Hao Chen,Ying Hao,Wenhui Hu,Zhongjin Yang +11 more
TL;DR: In this article, a hit-to-lead effort resulted in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors, and the most potent lead 40 exhibited improved inhibitory potency and almost no toxicity.
21
Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome
TL;DR: The preliminary mechanism study revealed that PTL mediated anti-inflammation is associated with the NLRP3 inflammasome signal pathway, and it is proposed that 8b might be a potential drug candidate for ultimate development of the anti- inflammation drug.
15
Compound AD16 Reduces Amyloid Plaque Deposition and Modifies Microglia in a Transgenic Mouse Model of Alzheimer's Disease.
Ping Sun,Hu Yue,Qi Xing,Wenmin Deng,Yitao Ou,Guangjin Pan,Xiaofen Zhong,Wenhui Hu +7 more
- 18 Nov 2020
TL;DR: This study studied the properties of microglial modification of AD16 in the AD mice model and found that AD16 decreased senescent microglia cells marked with SA-β-gal staining, and altered lysosomal positioning, enhanced Lysosomal Associated Membrane Protein 1 (LAMP1) expression, and elevated adenosine triphosphate (ATP) concentration were found with AD16 treatment.
12