Ping Lu
Harvard University
8 Papers
27 Citations
Ping Lu is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & SWI/SNF. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Ping Lu include University of Iowa & Roy J. and Lucille A. Carver College of Medicine.
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Papers
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.
Burak H. Alver,Kimberly H. Kim,Ping Lu,Ping Lu,Xiaofeng Wang,Xiaofeng Wang,Haley E. Manchester,Haley E. Manchester,Weishan Wang,Weishan Wang,Jeffrey R. Haswell,Jeffrey R. Haswell,Peter J. Park,Charles W. M. Roberts +13 more
TL;DR: It is shown via ChIP-seq and biochemical assays that SWI/SNF complexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to modulate histone H3 lysine 27 acetylation, establishingSWI/ SNF complexes as regulators of the enhancer landscape and providing insight into the roles of SWI-SNF in cellular fate control.
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters
Michael Y. Tolstorukov,Courtney G. Sansam,Courtney G. Sansam,Ping Lu,Ping Lu,Edward C. Koellhoffer,Edward C. Koellhoffer,Katherine C. Helming,Katherine C. Helming,Burak H. Alver,Erik J. Tillman,Erik J. Tillman,Julia A. Evans,Julia A. Evans,Boris G. Wilson,Boris G. Wilson,Peter J. Park,Peter J. Park,Charles W. M. Roberts,Charles W. M. Roberts +19 more
TL;DR: It is found that inactivation of either subunit of the mammalian Swi/Snf complex leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosomes occupancy at a large number of promoters, regardless of their association with CpG islands.
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The Developmental Regulator Protein Gon4l Associates with Protein YY1, Co-repressor Sin3a, and Histone Deacetylase 1 and Mediates Transcriptional Repression
Ping Lu,Isaiah L. Hankel,Bruce S. Hostager,Julie A. Swartzendruber,Ann D. Friedman,Janet L. Brenton,Paul B. Rothman,John D. Colgan +7 more
TL;DR: The identification of factors that interact with Gon4l and may cooperate with this protein to regulate gene expression are described and it is suggested that Sin3a, HDAC1, and YY1 are co-factors for Gon 4l and that Gon4L may function as a platform for the assembly of complexes that regulate geneexpression.
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The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis
Ping Lu,Isaiah L. Hankel,Judit Knisz,Andreas Marquardt,Ming Yi Chiang,Johannes Grosse,Rainer Constien,Thomas F. Meyer,Andreas Schroeder,Lutz Zeitlmann,Umaima Al-Alem,Ann D. Friedman,Eric I. Elliott,David K. Meyerholz,Thomas J. Waldschmidt,Paul B. Rothman,John D. Colgan +16 more
TL;DR: It is indicated that the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expression during this process and the levels of RNA encoding C/EBPα and PU1 were abnormally high in mutant B cell progenitors.
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Sedimentation and Immunoprecipitation Assays for Analyzing Complexes that Repress Transcription
TL;DR: A density gradient fractionation method for determining whether a co-repressor is incorporated into high-molecular complexes within cells and for identifying potential constituents of these complexes is described.