Ping Lu
University of Manitoba
6 Papers
Ping Lu is an academic researcher from University of Manitoba. The author has contributed to research in topics: Poly ADP ribose polymerase & Chemistry. The author has an hindex of 5, co-authored 6 publications.
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Papers
Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice.
TL;DR: Discovery of an endothelial receptor that regulates brain hyperemia provides insight into how neuronal activity couples with endothelial cells in vivo, and is related to eNMDAR loss-of-function mice.
64
Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons.
Ping Lu,Adam D. Hogan-Cann,Amit Kamboj,Subir K. Roy Chowdhury,Mohamad-Reza Aghanoori,Paul Fernyhough,Christopher M. Anderson +6 more
TL;DR: MNNG effects were mitigated by PARP1 inhibition and genetic loss offunction, by enhancing intracellular NAD+ levels, and with sirtuin (SIRT1) gain of function, supporting a mechanism dependent on PARP 1 activity, NAD+-depletion and SIRT1 inhibition.
21
Activation of Cannabinoid Receptors Attenuates Endothelin-1-Induced Mitochondrial Dysfunction in Rat Ventricular Myocytes.
Yan Lu,Danielle I. Lee,Subir K. Roy Chowdhury,Ping Lu,Amit Kamboj,Christopher M. Anderson,Paul Fernyhough,Hope D. Anderson +7 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated.
12
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis
Amit Kamboj,Ping Lu,Michael Cossoy,Jillian L. Stobart,Brian A Dolhun,Tiina M. Kauppinen,Gilbert de Murcia,Christopher M. Anderson +7 more
TL;DR: This is the first description of a significant role for PARP-2 in neuroinflammation and neurological dysfunction in EAE and significantly reduced overall disease burden and peak neurological dysfunction.
Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors.
Lingling Lu,Adam D. Hogan-Cann,Andrea K Globa,Ping Lu,James I. Nagy,Shernaz X. Bamji,Christopher M. Anderson +6 more
TL;DR: The observations identify a novel astrocyte-endothelial vasodilatory signaling axis that could contribute to endothelium-dependent vasodilation in brain functional hyperemia.