4 Papers
28 Citations
Ping Li is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 4, co-authored 4 publications.
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Papers
The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of FcγRIII (CD16)
TL;DR: Data demonstrate that a covalent modification of an Ig superfamily receptor at the carboxyl terminus of the ectodomain can have an impact on ligand bindingKinetic rates and affinity are measured and it is shown that the anchor influenced kinetic rates.
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Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors.
TL;DR: The agreement between experiment and theory supports the validity of the model, which could be useful in predicting the efficacy of the competitor, and relates cell-surface adhesion to the concentration of the soluble competitor, the densities of the surface-bound receptors and ligands, as well as the binding affinities ofThe 2D and 3D interactions.
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Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcγ receptors
TL;DR: Results demonstrate that CD16A-Ig forms a high avidity dimer and is capable of blocking cell-cell interactions mediated by inflammatory cells expressing FcgammaR and IgG-coated target cells and suggest that the dimeric FcGammaR molecules could be used therapeutically for the intervention of immune complex-mediated inflammatory disease.
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Affinity and Kinetic Analysis of Fcγ Receptor IIIa (CD16a) Binding to IgG Ligands
TL;DR: The kinetics and affinities measured by surface plasmon resonance agreed with those obtained from real time flow cytometry and competition inhibition binding experiments using cell surface CD16a, adding to the understanding of IgG-FcγR interactions.