Ping Li
Harvard University
2 Papers
26 Citations
Ping Li is an academic researcher from Harvard University. The author has contributed to research in topics: Phosphorylation & Tachykinin receptor 1. The author has an hindex of 2, co-authored 2 publications.
Chat about Author
Papers
Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.
TL;DR: It is demonstrated that mouse cells deficient in both c-Abl and Arg exhibit increased catalase stability and thatCatalase is subject to ubiquitination and degradation by the 26S proteosome, and in concert with these results, human 293 cells expressing catalases mutated at Y231 and Y386 exhibit attenuated levels of reactive oxygen species when exposed to hydrogen peroxide.
111
Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
TL;DR: The results show that Arg is stabilized in response to 0.1 mM H2O2 by autophosphorylation of Y-261, consistent with involvement of the Arg kinase function in regulating Arg levels, and that Arg stability is conferred by phosphorylated Y- 261.
29