6 Papers
74 Citations
Ping Li is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Cytotoxicity & Cytoskeleton. The author has an hindex of 4, co-authored 6 publications.
Chat about Author
Papers
The N-terminus of PrP is responsible for interacting with tubulin and fCJD related PrP mutants possess stronger inhibitive effect on microtubule assembly in vitro.
Chenfang Dong,Song Shi,Xiao-Fan Wang,Run An,Ping Li,Jian-Ming Chen,Xin Wang,Gui-Rong Wang,Bing Shan,Bao-Yun Zhang,Jun Han,Xiao-Ping Dong +11 more
TL;DR: The molecular interaction between PrP and tubulin was confirmed using pull-down assays, immunoprecipitation and ELISA and the familial Cruetzfeldt Jacob disease related PrP mutants with inserted or deleted octapeptide repeats showed much stronger inhibitive capacities on the microtubule dynamics in vitro than wild-type PrP.
55
PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.
Run An,Chenfang Dong,Yan-Jun Lei,Yan-Jun Lei,Lu Han,Ping Li,Jian-Ming Chen,Gui-Rong Wang,Qi Shi,Chen Gao,Hui-Ying Jiang,Wei Zhou,Jun Han,Yonglie Chu,Xiao-Ping Dong +14 more
TL;DR: Data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation, which may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases.
16
Transient expressions of doppel and its structural analog prionΔ32-121 in SH-SY5Y cells caused cytotoxicity possibly by triggering similar apoptosis pathway
Kun Xu,Xiao-Fan Wang,Chan Tian,Song Shi,Gui-Rong Wang,Qi Shi,Ping Li,Rui-Min Zhou,Hui Jiang,Y. L. Chu,Xiao-Ping Dong +10 more
TL;DR: Data highly indicate that cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process, probably triggering the mitochondrial pathway.
6
•Journal Article
Expression of recombinant human doppel protein and analysis of its cytotoxic activities
TL;DR: Results indicate that Dpl protein possesses cytotoxic activity in vitro, with obvious tissue-specific characteristics, and provides the foundation for further study of Dpl biological functions in vitro and in vivo.
2