Hepatitis B virus (HBV) infection still remains a major public health issue in the Asia–Pacific region. Most of the burden of HBV-related disease results from infections acquired in infancy through perinatal or early childhood exposure to HBV in Asia–Pacific. Hepatitis B during pregnancy presents unique management issues for both the mother and fetus. These APASL guidelines provide a comprehensive review and recommendations based on available evidence in the literature, for the management of females with HBV infection through every stage of pregnancy and postpartum. These also address the concerns, management challenges, and required follow-up of children born to hepatitis B-positive mothers. 

/pdf/asian-pacific-association-for-the-study-of-liver-apasl-ujrwtzq2.pdf

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

The impact of biparental hepatitis B virus infection on pregnancy outcomes in patients undergoing assisted reproductive technology treatment: a systematic review and meta-analysis

To develop the evidence-based guidelines for managing mother-to-child transmission of hepatitis B virus in China, a multidisciplinary guideline development group was established. Clinical questions were identified from two rounds of surveys on the concerns of first-line clinicians. We conducted a comprehensive search and review of the literature. A grading of recommendations' assessment, development, and evaluation system was adopted to rate the quality of evidence and the strength of recommendations. Recommendations were formulated based on the evidence, overall balance of benefits and harms (at individual and population levels), patient/health worker values and preferences, resources available, cost-effectiveness, and feasibility. Eventually, recommendations related to 13 main clinical concerns were developed, covering diagnostic criteria, treatment indications, antiviral therapy choice, timing to initiate and discontinue treatment, immunoprophylaxis strategy at birth, and how to deal with special situations, such as unintended pregnancy, assisted reproduction, and breastfeeding. The guidelines are intended to serve as guidance for clinicians and patients, to optimize the management of majority of pregnant women who are positive for hepatitis B surface antigen. Guideline registration: International Practice Guide Registration Platform (IPGRP-2018CN040).

/pdf/2019-chinese-clinical-practice-guidelines-for-the-prevention-5cw4pl1mm8.pdf

2019 Chinese Clinical Practice Guidelines for the Prevention of Mother-to-child Transmission of Hepatitis B Virus.

Objective
To investigate the effects of hepatitis B virus (HBV) in women with different ovarian reserve on outcomes of in vitro fertilization and embryo transfer (IVF-ET).


Methods
The clinical data of 1 310 patients were retrospectively analyzed, who were divided into three groups according to serum anti-Mullerian hormone (AMH) level: low ovarian reserve group (group A, AMH 7礸/L). Each group was divided into two groups: HBV carrier group and control group. The normal fertilization rate, the cleavage rate, the rate of good-quality embryos, the implantation rate, the clinical pregnancy rate and the abortion rate were compared.


Results
There was no significant difference between the HBV carrier group and control group in normal fertilization rate, the cleavage rate, the rate of good-quality embryos, the implantation rate and the clinical pregnancy rate (P>0.05). But in group A, the rate of no transferrable embryos of HBV carrier group was higher than that of control group with significant difference (P<0.05). In group B, the normal fertilization rate (69.8%), the cleavage rate (96.97%), the rate of good-quality embryos (21.8%), the implantation rate (31.3%), and the clinical pregnancy rate (44.1%) of HBV carrier group were all lower than those of control group (73.6%, 98.6%, 26.2%, 41.3%, 59.8%) with significant difference (P<0.05). In three groups, the abortion rate of HBV carrier group was all higher than that of control group with significant difference (P<0.05).


Conclusion
HBV carrier in women of low ovarian reserve and normal ovarian reserve group could affect the outcomes of IVF-ET treatment.


Key words: 
Hepatitis B virus; Ovarian reserve; In vitro fertilization and embryo transfer (IVF-ET)

Effects of hepatitis B virus infection in women with different ovarian reserve on outcomes of in vitro fertilization and embryo transfer

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Effects of hepatitis B virus infection in women with different ovarian reserve on outcomes of in vitro fertilization and embryo transfer