18 Papers
17 Citations
Ping Li is an academic researcher from Shandong University of Traditional Chinese Medicine. The author has contributed to research in topics: Influenza A virus & Biology. The author has an hindex of 5, co-authored 9 publications.
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Papers
Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors.
Ping Li,Ruikun Du,Yanyan Wang,Xuewen Hou,Lin Wang,Xiujuan Zhao,Peng Zhan,Xinyong Liu,Lijun Rong,Qinghua Cui +9 more
TL;DR: CHLA and CHLI are promising new NA inhibitors that may be further developed as novel antiviral therapies against IAVs.
Identification of novel inhibitors for SARS-CoV-2 as therapeutic options using machine learning-based virtual screening, molecular docking and MD simulation
Abdus Samad,Amar Ajmal,Arif Mahmood,Beenish Khurshid,Ping Li,Syed Mansoor Jan,Ashfaq Ur Rehman,Pei He,Ashraf N. Abdalla,Muhammad Umair,Junjian Hu,Abdul Wadood +11 more
TL;DR: In this paper , a machine learning-based virtual screening was performed to predict the active phytochemicals against the SARS-CoV-2 3-Chymotrypsin-like protease (3CLPRO), which can be used as a potential drug target.
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Punicalagin is a neuraminidase inhibitor of influenza viruses.
Ping Li,Ruikun Du,Zinuo Chen,Yanyan Wang,Peng Zhan,Xinyong Liu,Dongwei Kang,Zhaoyu Chen,Xiujuan Zhao,Lin Wang,Lijun Rong,Qinghua Cui +11 more
TL;DR: Punicalagin from plants possesses strong anti‐influenza activity with a low micromolar IC50 value in tissue culture, and can inhibit replication of different strains of influenza A and B viruses, including oseltamivir‐resistant virus, indicating that punicalagin is a broad spectrum antiviral against both IAV and IBV.
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Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.
Irina N. Gaisina,Norton P. Peet,Han Cheng,Ping Li,Ruikun Du,Qinghua Cui,Kevin Furlong,Balaji Manicassamy,Balaji Manicassamy,Michael Caffrey,Gregory R. J. Thatcher,Lijun Rong +11 more
TL;DR: Fast-acting, orally bioavailable acylated 4-aminopiperidines with an effective mechanism of action targeting viral hemagglutinin (HA) are discovered and show that these compounds are potent entry inhibitors of influenza A viruses.
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A Mechanism Underlying Attenuation of Recombinant Influenza A Viruses Carrying Reporter Genes.
Xiujuan Zhao,Lin Wang,Qinghua Cui,Ping Li,Yanyan Wang,Yingying Zhang,Yong Yang,Lijun Rong,Ruikun Du +8 more
TL;DR: A mechanism underlying attenuation of reporter IAVs is unraveled, which suggests a new approach to restore infectivity and virulence by introducing extra mutations compensating for the impaired replication property of corresponding segments.
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