Ping He
20 Papers
4 Citations
Ping He is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 19 publications.
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Papers
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of Concern
Dongyan Xiong,Xiaoxu Zhang,Mengjuan Shi,Nuo Wang,Ping He,Zhuo Dong,Jie Zhong,Jin Luo,Yong Wang,Junping Yu,Hongping Wei +10 more
TL;DR: The ARMS-RT-qPCR assay could be used for screening the two highly concerning variants Alpha and Delta by normal PCR laboratories in airports and in hospitals and other health-related organizations.
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A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape
Bo Feng,Zhilong Chen,Jing Sun,Tingting Xu,Qian Wang,Haisu Yi,Xuefeng Niu,Jiabin Zhu,Mengzhu Fan,Rui-tian Hou,Ying Shao,Sihui Huang,Cuiyun Li,Peiyu Hu,Pingqian Zheng,Ping He,Jia Luo,Qihong Yan,Xiaoli Xiong,Jinsong Liu,Jincun Zhao,Ling Chen +21 more
TL;DR: It is found that the S375F mutation on Omicron RBD disrupts the structure of β‐strand, thus impair the binding with 20G6, and demonstrates that shark‐derived vnarbodies offer a prophylactic and therapeutic option against most SARS‐CoV‐2 variants and provide insights into antibody evasion by the OmicRON variant.
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Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants
Qihong Yan,Rui-tian Hou,Xiaohan Huang,Yanjun Zhang,Ping He,Yudi Zhang,Banghui Liu,Qian Wang,Haiyue Rao,Xianying Chen,Xinwei Zhao,Xuefeng Niu,Jincun Zhao,Xiaoli Xiong,Ling Chen +14 more
TL;DR: Findings support that IGHV1-69 population antibodies contribute to selection pressure for L452 substitution, and provides better understanding of SARS-CoV-2 variant genesis and immune evasion.
19
Steep Decline in Binding Capability of SARS-CoV-2 Omicron Variant (B.1.1.529) RBD to the Antibodies in Early COVID-19 Convalescent Sera and Inactivated Vaccine Sera
TL;DR: The results showed that the Omicron variant may evade antibodies induced by the ancestral strain and by the inactivated vaccine, with significant reduction in the binding capability of its RBD much greater than that of the Delta variant.
Discovering covalent inhibitors of protein-protein interactions from trillions of sulfur(VI) fluoride exchange-modified oligonucleotides.
Zichen Qin,Kaining Zhang,Ping He,Xue Zhang,Miao Xie,Yucheng Fu,Chunmei Gu,Yiying Zhu,Aijun Tong,Hongping Wei,Chuan hai Zhang,Yu Xiang +11 more
TL;DR: With SuFEx in vitro selection, covalent inhibitors that cross-link distinct residues of the SARS-CoV-2 spike protein at its protein-protein interaction interface with the human angiotensin-converting enzyme 2 are identified and a clear disconnection between binding affinity and cross-linking reactivity is observed.
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