Ping Fan

TL;DR: These studies suggest that secondary resistance to hormonal therapy results in usage of both IGF-R and EGF-R for non-genomic signaling, and suggests that both the EGF/IGF-R pathways can mediate ERalpha signaling.

TL;DR: It is found that the mTOR pathway plays the primary role in mediation of proliferation of LTED cells, and different mechanisms are involved in acquired endocrine resistance and the necessity for individualized treatment of recurrent diseases is suggested.

TL;DR: The results suggest that the effects of E(2) on cell migration involve multiple, interacting signaling pathways mediated by the MAPK, phosphatidylinositol 3 kinase, and c-Jun N-terminal kinase pathways and each pathway represents a potential target for blocking cell migration and metastasis of breast cancer cells.

TL;DR: In order to abrogate growth factor induced hypersensitivity, a drug is utilized, farnesylthiosalicylic acid, which blocks the binding of GTP-Ras to its membrane acceptor protein, galectin 1 and reduces the activation of MAP kinase, which provides the major means for inhibition of cell proliferation.