Pierre Mangin
University of Strasbourg
97 Papers
355 Citations
Pierre Mangin is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 32, co-authored 82 publications. Previous affiliations of Pierre Mangin include University of Melbourne & Paris Descartes University.
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Papers
A revised model of platelet aggregation
Suhasini Kulkarni,Sacha M Dopheide,Cindy L. Yap,Catherine Ravanat,Monique Freund,Pierre Mangin,Kathryn A Heel,Kathryn A Heel,Alison Street,Ian S. Harper,François Lanza,Shaun P. Jackson +11 more
TL;DR: An important role for platelet vWf in initiating the platelet aggregation process under flow is demonstrated and the currently accepted view that the vWF-GPIbalpha interaction is exclusively involved in initiating platelet aggregating at elevated shear rates is challenged.
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.
Elmina Mammadova-Bach,Véronique Ollivier,Véronique Ollivier,Stéphane Loyau,Stéphane Loyau,Mathieu Schaff,Bénédicte Dumont,Bénédicte Dumont,Rémi Favier,Geneviève Freyburger,Véronique Latger-Cannard,Bernhard Nieswandt,Christian Gachet,Pierre Mangin,Martine Jandrot-Perrus,Martine Jandrot-Perrus +15 more
TL;DR: GPVI is identified as a platelet receptor for polymerized fibrin with 2 major functions: amplification of thrombin generation and recruitment of circulating platelets to clots.
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Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
Sylvie Moog,Pierre Mangin,Nadège Lenain,Catherine Strassel,Catherine Ravanat,Simone Schuhler,Monique Freund,Martine Santer,Mark L. Kahn,Bernhard Nieswandt,Christian Gachet,Jean-Pierre Cazenave,François Lanza +12 more
TL;DR: GPV binds to collagen and appears to be required for normal platelet responses to this agonist, as demonstrated in aggregation and surface plasmon resonance studies.
133
Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets
Soochong Kim,Pierre Mangin,Carol Dangelmaier,Rivka Lillian,Shaun P. Jackson,James L. Daniel,Satya P. Kunapuli +6 more
TL;DR: GPVI-induced Akt activation in platelets is dependent in part on Gi stimulation through P2Y12 receptor activation by secreted ADP, and PI3Kβ plays an essential role in GPVI-mediated platelet aggregation and Aktactivation.
132
Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.
Nadezhda A. Podoplelova,Anastasia N. Sveshnikova,Yana N. Kotova,Anita Eckly,Nicolas Receveur,Dmitry Yu. Nechipurenko,Sergey I. Obydennyi,Igor I. Kireev,Christian Gachet,Fazly I. Ataullakhanov,Pierre Mangin,Mikhail A. Panteleev +11 more
TL;DR: An essential heterogeneity in the surface distribution of major coagulation factors on the surface of procoagulant platelets is revealed and its importance in promoting membrane-dependent coagulated reactions is suggested.
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