Pierre Adnot
Merck & Co.
4 Papers
51 Citations
Pierre Adnot is an academic researcher from Merck & Co.. The author has contributed to research in topics: Lipolysis & Islet. The author has an hindex of 3, co-authored 4 publications.
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Papers
Resistance to the Lipolytic Action of Epinephrine: A New Feature of Protein Gs Deficiency
Jean Claude Carel,Catherine Le Stunff,Luce Condamine,Luce Condamine,Eric Mallet,Chaussain Jl,Pierre Adnot,Michèle Garabédian,Pierre Bougnères +8 more
TL;DR: Findings extend the spectrum of hormonal resistance in Gs deficiency to include beta-adrenergic receptors, and Gs protein itself should be examined as a possible step involved in the decreased lipolysis observed in common obesity.
Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion.
Christophe Magnan,Céline Cruciani,Laurence Clement,Pierre Adnot,Mylène Vincent,Micheline Kergoat,Arlette Girard,Jean-Luc Elghozi,Gilberto Velho,Nathalie Beressi,Jean-Louis Bresson,Alain Ktorza +11 more
TL;DR: In healthy subjects, a 48-h lipid infusion induces basal hyperinsulinemia and exaggerated insulin secretion in response to glucose which may be partly related to a decrease in sympathetic tone.
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Pancreatic β‐cell α2A adrenoceptor and phospholipid changes in hyperlipidemic ratsadrenoceptor and phospholipid changes in hyperlipidemic rats
Laurence Clement,K.A. Kim-Sohn,Christophe Magnan,Nadim Kassis,Pierre Adnot,Micheline Kergoat,Françoise Assimacopoulos-Jeannet,Luc Pénicaud,Fong-Fu Hsu,John Turk,Alain Ktorza +10 more
TL;DR: This article showed that a 48-h increase in plasma FFA alters the binding characteristics of β-cell α2 adrenoceptors in rats, leading to increased sensitivity to catecholamines.
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•Journal Article
Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia.
Christophe Magnan,Marie-Claude Laury,Pierre Adnot,L. Doaré,L. Boucontet,Micheline Kergoat,Luc Pénicaud,Alain Ktorza,Marc Gilbert +8 more
TL;DR: It is concluded that 48 h of hyperglycaemia/hyperinsulinaemia resulted in a failure of counterregulatory hormonal response to hypoglycaemia, yet, despite this lack ofcounterregulatory response, hepatic gluconeogenesis was stimulated in response to Hypoglycaememia.
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