Pier Andrea Borea
University of Ferrara
347 Papers
3.9K Citations
Pier Andrea Borea is an academic researcher from University of Ferrara. The author has contributed to research in topics: Adenosine receptor & Adenosine. The author has an hindex of 63, co-authored 336 publications.
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Papers
Binding Thermodynamics as a Tool To Investigate the Mechanisms of Drug−Receptor Interactions: Thermodynamics of Cytoplasmic Steroid/Nuclear Receptors in Comparison with Membrane Receptors
Paola Gilli,Gastone Gilli,Pier Andrea Borea,Katia Varani,and Angelo Scatturin,Alessandro Dalpiaz +5 more
TL;DR: Binding thermodynamics of estradiol, ORG2058, and R1881 bound to estrogen, progesterone, and androgen steroid/nuclear receptors, respectively, as determined by variable-temperature binding constant measurements are reported.
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Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.
Vittoria Colotta,Francesca Capelli,Ombretta Lenzi,Daniela Catarzi,Flavia Varano,Daniela Poli,Fabrizio Vincenzi,Katia Varani,Pier Andrea Borea,Diego Dal Ben,Rosaria Volpini,Gloria Cristalli,Guido Filacchioni +12 more
TL;DR: An intensive molecular docking study to a rhodopsin-based homology model of the hA(3) receptor was carried out to obtain a 'structure-based pharmacophore model' that proved to be helpful for the interpretation of the observed affinities of the new hA (3) pyrazoloquinoline antagonists.
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Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
Mojgan Aghazadeh Tabrizi,Pier Giovanni Baraldi,Giulia Saponaro,Allan R. Moorman,Romeo Romagnoli,Delia Preti,Stefania Baraldi,Carmen Corciulo,Fabrizio Vincenzi,Pier Andrea Borea,Katia Varani +10 more
TL;DR: It is found that the functionality of these ligands is controlled by the nature of the heteroaryl function condensed with the pyridine ring, and in 3,5-cyclic adenosine monophosphate (cAMP) assays, the novel series show dose-dependent effects on the modulation of forskolin-induced cAMP production.
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Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo(3,4-c)quinoline derivatives as adenosine receptor antagonists
Ombretta Lenzi,Vittoria Colotta,Daniela Catarzi,Flavia Varano,Lucia Squarcialupi,Guido Filacchioni,Katia Varani,Fabrizio Vincenzi,Pier Andrea Borea,Diego Dal Ben,Catia Lambertucci,Gloria Cristalli +11 more
TL;DR: The study of new 2-phenyl- and 2-methylpyrazolo[3,4-c]quinolin-4-ones and 4-amines, designed as adenosine receptor (AR) antagonists, finds that modification was not tolerated since it reduced AR affinity, while in series B it shifted the binding towards the hA(1) subtype.
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Stereochemistry of benzodiazepine receptor ligands. Possible role of C–H ⋯ X interactions in drug–receptor binding and crystal structures of CL218–872, Zopiclone and DMCM
TL;DR: The crystal structures of three benzodiazepine (BDZ)-receptor ligands, i.e. CL218-872, Zopiclone and DMCM, are reported in this paper.
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