Phylip Chen
Nationwide Children's Hospital
14 Papers
1 Citations
Phylip Chen is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Phylip Chen include Ohio State University.
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Papers
DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN
Fatih Ozaltin,Binghua Li,Alysha Rauhauser,Sung Wan An,Oguz Soylemezoglu,İpek Işık Gönül,Ekim Z. Taskiran,Tulin Ibsirlioglu,Emine Korkmaz,Yelda Bilginer,Ali Duzova,Seza Ozen,Rezan Topaloglu,Nesrin Besbas,Shazia Ashraf,Shazia Ashraf,Yong Du,Chaoying Liang,Phylip Chen,Dongmei Lu,Komal Vadnagara,Susan Arbuckle,Deborah Lewis,Benjamin E. Wakeland,Richard J. Quigg,Richard F. Ransom,Edward K. Wakeland,Matthew K. Topham,Nicolas G. Bazan,Chandra Mohan,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Aysin Bakkaloglu,Chou Long Huang,Massimo Attanasio +34 more
TL;DR: The results not only identify a genetic cause of a glomerular microangiopathy but also suggest that the phosphatidylinositol cycle, which requires DGKE, is critical to the normal function of podocytes.
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Yuexiu Zhang,Li-Sheng Zhang,Qing Dai,Phylip Chen,Mijia Lu,E. Kairis,Valarmathy Murugaiah,Jiayu Xu,Rajni Kant Shukla,Xueya Liang,Zhongyu Zou,Estelle Cormet-Boyaka,Jianbin Qiu,Mark E. Peeples,Amit Sharma,Chuan He,Jiànróng Lǐ +16 more
TL;DR: It is found that depletion of NSUN2, an m5C methyltransferase, significantly inhibits the replication and gene expression of a wide range of RNA and DNA viruses and is largely driven by an enhanced type I interferon (IFN) response.
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Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats
Darren Wethington,Olivia Harder,Karthik Uppulury,William C. L. Stewart,William C. L. Stewart,Phylip Chen,Tiffany King,Tiffany King,Susan D. Reynolds,Susan D. Reynolds,Alan S. Perelson,Mark E. Peeples,Mark E. Peeples,Stefan Niewiesk,Jayajit Das +14 more
TL;DR: The combined approach quantified the importance of the adaptive immune response in suppressing RSV infection in cotton rats, which could be useful in testing RSV vaccine candidates.
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Type-III Interferons, Viral Loads, Age, and Disease Severity in Young Children with Respiratory Syncytial Virus Infection.
Jeanette Taveras,Cristina Garcia-Maurino,Melissa Moore-Clingenpeel,Zhaohui Xu,Sara Mertz,Fang Ye,Phylip Chen,Shira Cohen,Daniel M. Cohen,Mark E. Peeples,Octavio Ramilo,Asuncion Mejias +11 more
TL;DR: Children with milder RSV infection and those >6 months had higher concentrations of mucosal IFNs, suggesting that maturation of mucosa IFN responses are associated with protection against severe RSV disease.
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High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells
İrem Deniz Derman,Miji Yeo,Diana Cadena Castaneda,Megan Callender,Mian Horvath,Zengshuo Mo,Ruoyun Xiong,Elizabeth Fleming,Phylip Chen,Mark E. Peeples,A. Karolina Palucka,Julia Oh,Ibrahim T. Ozbolat +12 more
TL;DR: The results denote the potential of 3D bioprinting for high-throughput fabrication of nasal epithelial tissue models not only for infection studies but also for other purposes, such as disease modeling, immunological studies, and drug screening.
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