Phuong T. Le
Maine Medical Center
45 Papers
36 Citations
Phuong T. Le is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Bone resorption & Medicine. The author has an hindex of 20, co-authored 37 publications.
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Papers
Stem cell-based therapy for human diseases
Duc Manh Hoang,Phuong Tran Pham,T. Q. Bach,Anh T L Ngo,Q. T. Nguyen,Trang Phan,Giang H. Nguyen,Phuong T. Le,Van T. Hoang,Nicholas R. Forsyth,Michael Heke,Liem T. Nguyen +11 more
TL;DR: In this article , a review provides an update on recent clinical applications using either human pluripotent stem cells (hPSCs) or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions.
Parathyroid hormone directs bone marrow mesenchymal cell fate.
Yi Fan,Yi Fan,Jun-ichi Hanai,Phuong T. Le,Ruiye Bi,Ruiye Bi,David E. Maridas,Victoria E. DeMambro,Carolina A. Figueroa,Serkan Kir,Xuedong Zhou,Michael Mannstadt,Roland Baron,Roderick T. Bronson,Mark C. Horowitz,Joy Y. Wu,John P. Bilezikian,David W. Dempster,Clifford J. Rosen,Beate Lanske +19 more
TL;DR: M marrow adipocytes exhibit osteogenic and adipogenic characteristics, are uniquely responsive to PTH, and secrete RANKL, which reveals an important mechanism for PTH's therapeutic action through its ability to direct mesenchymal cell fate.
362
Oxidative Stress Is Increased in Critically Ill Patients with Acute Renal Failure
Jonathan Himmelfarb,Ellen McMonagle,Stephanie Freedman,Jennifer Klenzak,Elizabeth McMenamin,Phuong T. Le,Lara B. Pupim,T. Alp Ikizler +7 more
TL;DR: Plasma protein oxidation is markedly increased in ARF patients compared with healthy subjects, ESRD patients, and critically ill patients and increased oxidative stress may be an important target for nutritional and pharmacologic therapy in ARf patients.
227
Liver homeostasis is maintained by midlobular zone 2 hepatocytes
Yonglong Wei,Yunguan Wang,Yuemeng Jia,Lin Li,Jung Yoon,Shuyuan Zhang,Zixi Wang,Yu Zhang,Min Zhu,Tripti Sharma,Yu Hsuan Lin,Meng Hsiung Hsieh,Jeffrey H. Albrecht,Phuong T. Le,Clifford J. Rosen,Tao Wang,Hao Zhu +16 more
TL;DR: In this paper, 14 murine fate-mapping strains were used to systematically compare distinct subsets of hepatocytes, showing that different regions of the lobule exhibit differences in their contribution to hepatocyte turnover.
220
ESRD Impairs Nonrenal Clearance of Fexofenadine but not Midazolam
Thomas D. Nolin,Reginald F. Frye,Phuong T. Le,Hooman Sadr,Judith Naud,François A. Leblond,Vincent Pichette,Jonathan Himmelfarb +7 more
TL;DR: Findings demonstrate a mechanism for altered drug disposition in kidney disease, which may partially account for the high rates of drug toxicity in this population of patients with ESRD and healthy control subjects.