Phillippa C. Taberlay
University of Tasmania
34 Papers
75 Citations
Phillippa C. Taberlay is an academic researcher from University of Tasmania. The author has contributed to research in topics: Epigenetics & Biology. The author has an hindex of 14, co-authored 28 publications. Previous affiliations of Phillippa C. Taberlay include University of New South Wales & Garvan Institute of Medical Research.
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Papers
Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations
Phillippa C. Taberlay,Joanna Achinger-Kawecka,Aaron T. L. Lun,Fabian A. Buske,Kenneth S. Sabir,Cathryn M. Gould,Elena Zotenko,Saul A. Bert,Katherine A. Giles,Denis C. Bauer,Gordon K. Smyth,Clare Stirzaker,Seán I. O'Donoghue,Susan J. Clark +13 more
TL;DR: It is found that cancer cells retain the ability to segment their genomes into megabase-sized topologically associated domains (TADs); however, these domains are generally smaller due to establishment of additional domain boundaries.
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival
Daniel D. De Carvalho,Shikhar Sharma,Jueng Soo You,Sheng-Fang Su,Phillippa C. Taberlay,Theresa K. Kelly,Xiaojing Yang,Gangning Liang,Peter A. Jones +8 more
TL;DR: Experimental and bioinformatic approaches showed experimentally that these genes must be silenced by DNA methylation for cancer cell survival, suggesting these are key epigenetic events associated with tumorigenesis.
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The DNA methylation landscape in cancer.
TL;DR: The distribution of DNA methylation and DNA hydroxymethylation in different genomic contexts, first in normal cells, and how this is altered in cancer is described.
DNA methylation and cancer.
TL;DR: The importance of both established and novel molecular concepts that may underlie the role of DNA methylation in cancer are discussed, which suggest a role for histone octamers in the establishment ofDNA methylation patterns.
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Mining cancer methylomes: prospects and challenges
Clare Stirzaker,Phillippa C. Taberlay,Phillippa C. Taberlay,Aaron L. Statham,Susan J. Clark,Susan J. Clark +5 more
TL;DR: Approaches for methylome studies are discussed and compared and genome coverage of promoters, genes, and intergenic regions, and capacity to quantitate individual CpG methylation states are compared.
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