Phillip M. Brailey
King's College London
4 Papers
13 Citations
Phillip M. Brailey is an academic researcher from King's College London. The author has contributed to research in topics: Intrinsic immunity & Antigen. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Phillip M. Brailey include George Washington University & Francis Crick Institute.
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Papers
IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis
Rui André Saraiva Raposo,Miguel de Mulder Rougvie,Dominic Paquin-Proulx,Phillip M. Brailey,Vinicius D. Cabido,Paul M. Zdinak,Allison S. Thomas,Szu-Han Huang,Greta A. Beckerle,Richard B. Jones,Douglas F. Nixon +10 more
TL;DR: It is hypothesized that IFITM1 could mark natural reservoirs, identifying an immune target for killing of latently infected cells, and could be explored to develop clinical therapeutic approaches to effectively eradicate HIV-1.
Patent
Methods and compositions targeting retroviral latency
Rui André Saraiva Raposo,Miguel de Mulder Rougvie,Dominic Paquin Proulx,Phillip M. Brailey,Vincius D. Cabido,Paul M. Zdinak,Richard Bradley Jones,Douglas F. Nixon +7 more
- 07 Apr 2017
TL;DR: In this paper, methods and compositions for identifying cells latently infected with and harboring an occult reservoir of infectious virus are provided for identifying and identifying cells that harboring a latent HIV infection.
2
Restriction Factor Expression in Vertically Infected Children Living With HIV-1.
Martin Bortlik,Martin Bortlik,Dennis C Copertino,Phillip M. Brailey,Phillip M. Brailey,Phillip M. Brailey,Greta A. Beckerle,Greta A. Beckerle,Christopher E. Ormsby,Michael G. Rosenberg,Michael G. Rosenberg,Andrew Wiznia,Andrew Wiznia,Rui André Saraiva Raposo,Douglas F. Nixon,Douglas F. Nixon,Miguel de Mulder Rougvie,Miguel de Mulder Rougvie +17 more
TL;DR: In this paper, the expression of host restriction factors in children living with HIV-1 was analyzed by flow cytometry and showed a significant positive correlation with viral load (P = 0.0006; ρ = -0.0008; O(n) = −0.22).
Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation.
Fabio E. Leal,Soraya Maria Menezes,Emanuela Avelar Silva Costa,Phillip M. Brailey,Lucio Gama,Aluísio Augusto Cotrim Segurado,Esper G. Kallas,Douglas F. Nixon,Tim Dierckx,Ricardo Khouri,Ricardo Khouri,Jurgen Vercauteren,Bernardo Galvão-Castro,Rui André Saraiva Raposo,Johan Van Weyenbergh +14 more
TL;DR: Ex vivo mechanistic evidence is provided for the observed immunovirological effect of in vivo IFN-β treatment in HAM/TSP, reconcile an apparent IFN paradox in HTLV-1 research and identify biomarkers/targets for a precision medicine approach.