Phillip L. Hagan
United States Department of Veterans Affairs
32 Papers
755 Citations
Phillip L. Hagan is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Monoclonal antibody & Carcinoembryonic antigen. The author has an hindex of 12, co-authored 32 publications. Previous affiliations of Phillip L. Hagan include University of California, San Diego.
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Papers
•Journal Article
Stability, Characterization, and Kinetics of 111In-labeled Monoclonal Antitumor Antibodies in Normal Animals and Nude Mouse-Human Tumor Models
Samuel E. Halpern,Phillip L. Hagan,P. Garver,James A. Koziol,Agnes Chen,James M. Frincke,Richard M. Bartholomew,Gary S. David,Adams Thomas Henry +8 more
TL;DR: The data indicate that 111In-MoAb may prove to be effective as a radiopharmaceutical for tumor imaging and follow a two-compartmental model when studied in nude mice bearing human colon tumors known to express carcinoembryonic antigen.
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•Journal Article
Tumor Size: Effect on Monoclonal Antibody Uptake in Tumor Models
Phillip L. Hagan,Samuel E. Halpern,Robert O. Dillman,D L Shawler,Duane E. Johnson,Agnes Chen,L Krishnan,James M. Frincke,Richard M. Bartholomew,Gary S. David +9 more
TL;DR: There is strong evidence for a decrease in per g uptake of labeled tumor specific antibodies as tumors increase in size.
145
Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: a preliminary report.
Samuel E. Halpern,R O Dillman,K. F. Witztum,J F Shega,Phillip L. Hagan,W M Burrows,J.B. Dillman,M L Clutter,R E Sobol,J.M. Frincke +9 more
TL;DR: The 96.5 In-111 MoAb appears to have utility for the detection of metastatic melanoma and is often better seen with single photon emission computed tomography than with planar imaging techniques.
106
Scintigraphy with In-111-labeled monoclonal antitumor antibodies: kinetics, biodistribution, and tumor detection.
Samuel E. Halpern,W Haindl,J Beauregard,Phillip L. Hagan,M L Clutter,Amox D,B Merchant,M Unger,C Mongovi,Richard M. Bartholomew +9 more
TL;DR: The distribution of each MoAb appears unique unto itself with regard to kinetics, normal tissue distribution, and response to MoAb mass.
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•Journal Article
Tissue distribution studies with radioactive manganese: a potential agent for myocardial imaging.
Depew M. Chauncey,Heinrich R. Schelbert,Samuel E. Halpern,F. Delano,M.L. McKegney,William L. Ashburn,Phillip L. Hagan +6 more
TL;DR: Radioactive manganese appears promising as an intravenous myocardial imaging agent, and might be useful in studying the function of myocardia mitochondria by external imaging.
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