Philippe Wyrsch
University of Zurich
7 Papers
6 Citations
Philippe Wyrsch is an academic researcher from University of Zurich. The author has contributed to research in topics: PARG & Cytotoxicity. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Philippe Wyrsch include ETH Zurich.
Chat about Author
Papers
The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection.
Senta M. Walton,Philippe Wyrsch,Michael W. Munks,Albert Zimmermann,Hartmut Hengel,Ann B. Hill,Annette Oxenius +6 more
TL;DR: It is demonstrated that the overall MCMV-specific CD4 T cell response stabilizes during the latent stage, which stands in contrast to subpopulations of MCMv- specific CD8 T cells and HCMV- specificCD4 T cells which accumulate over the course of CMV latency.
73
Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death.
TL;DR: It is shown that PARP-1 and PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins.
Cytosolic Ca2+ shifts as early markers of cytotoxicity.
TL;DR: A cytotoxicity assay based on Ca2+ shifts has a low limit of detection (LOD), is less time consuming compared to the cell viability assay Alamar Blue and is suitable for high-troughput-screening (HTS).
Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage
Theresa Pesch,Harald Schuhwerk,Harald Schuhwerk,Philippe Wyrsch,Timo A. Immel,Wilhelm G. Dirks,Alexander Bürkle,Thomas Huhn,Sascha Beneke,Sascha Beneke +9 more
TL;DR: It is demonstrated in four different human cell lines that tumor cells were specifically killed without induction of major cytotoxicity in non-tumorigenic cells, making Tc52 an attractive compound for further investigations in cancer treatment.
12
The sound of silence: RNAi in poly (ADP-Ribose) research
TL;DR: The potential of RNAi to manipulate the levels of PARPs and PARG, and consequently those of PAR and ADPR, are discussed, and the results with those obtained after genetic or chemical disruption are compared.
6