Philippe Seksik
University of Paris
230 Papers
624 Citations
Philippe Seksik is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Inflammatory bowel disease. The author has an hindex of 53, co-authored 196 publications. Previous affiliations of Philippe Seksik include Institut national de la recherche agronomique & Centre national de la recherche scientifique.
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Papers
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Epidemiology and Natural History of Inflammatory Bowel Diseases
TL;DR: It has been proposed that only aggressive therapeutic approaches, based on treatment of early recurrent lesions in asymptomatic individuals, have a significant impact on progression of these chronic diseases.
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Low counts of Faecalibacterium prausnitzii in colitis microbiota.
Harry Sokol,Philippe Seksik,Jean-Pierre Furet,Olivier Firmesse,Isabelle Nion-Larmurier,Laurent Beaugerie,Jacques Cosnes,Gérard Corthier,P Marteau,Joël Doré +9 more
TL;DR: The fecal microbiota of patients with IBD differs from that of healthy subjects, and the phylum Firmicutes and particularly the species F. prausnitzii, are underrepresented in A‐IBD patients as well as in IC patients, which could be crucial to gut homeostasis.
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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Bruno Lamas,Mathias L. Richard,Valentin Leducq,Hang-Phuong Pham,Marie-Laure Michel,Grégory Da Costa,Chantal Bridonneau,Sarah Jegou,Thomas W. Hoffmann,Jane M. Natividad,Loic Brot,Soraya Taleb,Soraya Taleb,Aurélie Couturier-Maillard,Isabelle Nion-Larmurier,Fatiha Merabtene,Philippe Seksik,Anne Bourrier,Jacques Cosnes,Bernhard Ryffel,Bernhard Ryffel,Laurent Beaugerie,Jean-Marie Launay,Philippe Langella,Ramnik J. Xavier,Harry Sokol +25 more
TL;DR: In this article, a relationship between the host and the gut microbiota govern intestinal homeostasis is revealed, and the authors reveal that host genes affect the composition and function of the Gut microbiota, altering the production of microbial metabolites and intestinal inflammation.
Fungal microbiota dysbiosis in IBD
Harry Sokol,Valentin Leducq,Hugues Aschard,Hang-Phuong Pham,Sarah Jegou,Cécilia Landman,David Cohen,David Cohen,Giuseppina Liguori,Anne Bourrier,Isabelle Nion-Larmurier,Jacques Cosnes,Philippe Seksik,Philippe Langella,David Skurnik,Mathias L. Richard,Laurent Beaugerie +16 more
TL;DR: It is observed that fungal microbiota is skewed in IBD, with an increased Basidiomycota/Ascomycota ratio, a decreased proportion of Saccharomyces cerevisiae and an increased proportion of Candida albicans compared with HS, indicating that a Crohn's disease-specific gut environment may favour fungi at the expense of bacteria.
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